Functional and connectivity correlates associated with Parkinson’s disease psychosis: a systematic review

TY - JOUR

T1 - Functional and connectivity correlates associated with Parkinson’s disease psychosis

T2 - a systematic review

AU - Pisani, Sara

AU - Gunasekera, Brandon

AU - Lu, Yining

AU - Vignando, Miriam

AU - Ffytche, Dominic

AU - Aarsland, Dag

AU - Chaudhuri, K. R.

AU - Ballard, Clive

AU - Lee, Jee Young

AU - Kim, Yu Kyeong

AU - Velayudhan, Latha

AU - Bhattacharyya, Sagnik

N1 - Publisher Copyright: © The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.

PY - 2024

Y1 - 2024

N2 - Neural underpinnings of Parkinson’s disease psychosis remain unclear to this day with relatively few studies and reviews available. Using a systematic review approach, here, we aimed to qualitatively synthesize evidence from studies investigating Parkinson’s psychosis-specific alterations in brain structure, function or chemistry using different neuroimaging modalities. PubMed, Web of Science and Embase databases were searched for functional MRI (task-based and resting state), diffusion tensor imaging, PET and single-photon emission computed tomography studies comparing Parkinson’s disease psychosis patients with Parkinson’s patients without psychosis. We report findings from 29 studies (514 Parkinson’s psychosis patients, mean age ± SD = 67.92 ± 4.37 years; 51.36% males; 853 Parkinson’s patients, mean age ± SD = 66.75 ± 4.19 years; 55.81% males). Qualitative synthesis revealed widespread patterns of altered brain function across task-based and resting-state functional MRI studies in Parkinson’s psychosis patients compared with Parkinson’s patients without psychosis. Similarly, white matter abnormalities were reported in parietal, temporal and occipital regions. Hypo-metabolism and reduced dopamine transporter binding were also reported whole brain and in sub-cortical areas. This suggests extensive alterations affecting regions involved in high-order visual processing and attentional networks.

AB - Neural underpinnings of Parkinson’s disease psychosis remain unclear to this day with relatively few studies and reviews available. Using a systematic review approach, here, we aimed to qualitatively synthesize evidence from studies investigating Parkinson’s psychosis-specific alterations in brain structure, function or chemistry using different neuroimaging modalities. PubMed, Web of Science and Embase databases were searched for functional MRI (task-based and resting state), diffusion tensor imaging, PET and single-photon emission computed tomography studies comparing Parkinson’s disease psychosis patients with Parkinson’s patients without psychosis. We report findings from 29 studies (514 Parkinson’s psychosis patients, mean age ± SD = 67.92 ± 4.37 years; 51.36% males; 853 Parkinson’s patients, mean age ± SD = 66.75 ± 4.19 years; 55.81% males). Qualitative synthesis revealed widespread patterns of altered brain function across task-based and resting-state functional MRI studies in Parkinson’s psychosis patients compared with Parkinson’s patients without psychosis. Similarly, white matter abnormalities were reported in parietal, temporal and occipital regions. Hypo-metabolism and reduced dopamine transporter binding were also reported whole brain and in sub-cortical areas. This suggests extensive alterations affecting regions involved in high-order visual processing and attentional networks.

KW - neural correlates

KW - neuroimaging

KW - Parkinson’s disease

KW - psychosis

KW - systematic review

UR - http://www.scopus.com/inward/record.url?scp=85208712626&partnerID=8YFLogxK

U2 - 10.1093/braincomms/fcae358

DO - 10.1093/braincomms/fcae358

M3 - Review article

AN - SCOPUS:85208712626

SN - 2632-1297

VL - 6

JO - Brain Communications

JF - Brain Communications

IS - 6

M1 - fcae358

ER -