TY - JOUR
T1 - Functional and connectivity correlates associated with Parkinson's disease psychosis
T2 - a systematic review
AU - Pisani, Sara
AU - Gunasekera, Brandon
AU - Lu, Yining
AU - Vignando, Miriam
AU - Ffytche, Dominic
AU - Aarsland, Dag
AU - Chaudhuri, K R
AU - Ballard, Clive
AU - Lee, Jee-Young
AU - Kim, Yu Kyeong
AU - Velayudhan, Latha
AU - Bhattacharyya, Sagnik
N1 - Publisher Copyright:
© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.
PY - 2024
Y1 - 2024
N2 - Neural underpinnings of Parkinson's disease psychosis remain unclear to this day with relatively few studies and reviews available. Using a systematic review approach, here, we aimed to qualitatively synthesize evidence from studies investigating Parkinson's psychosis-specific alterations in brain structure, function or chemistry using different neuroimaging modalities. PubMed, Web of Science and Embase databases were searched for functional MRI (task-based and resting state), diffusion tensor imaging, PET and single-photon emission computed tomography studies comparing Parkinson's disease psychosis patients with Parkinson's patients without psychosis. We report findings from 29 studies (514 Parkinson's psychosis patients, mean age ± SD = 67.92 ± 4.37 years; 51.36% males; 853 Parkinson's patients, mean age ± SD = 66.75 ± 4.19 years; 55.81% males). Qualitative synthesis revealed widespread patterns of altered brain function across task-based and resting-state functional MRI studies in Parkinson's psychosis patients compared with Parkinson's patients without psychosis. Similarly, white matter abnormalities were reported in parietal, temporal and occipital regions. Hypo-metabolism and reduced dopamine transporter binding were also reported whole brain and in sub-cortical areas. This suggests extensive alterations affecting regions involved in high-order visual processing and attentional networks.
AB - Neural underpinnings of Parkinson's disease psychosis remain unclear to this day with relatively few studies and reviews available. Using a systematic review approach, here, we aimed to qualitatively synthesize evidence from studies investigating Parkinson's psychosis-specific alterations in brain structure, function or chemistry using different neuroimaging modalities. PubMed, Web of Science and Embase databases were searched for functional MRI (task-based and resting state), diffusion tensor imaging, PET and single-photon emission computed tomography studies comparing Parkinson's disease psychosis patients with Parkinson's patients without psychosis. We report findings from 29 studies (514 Parkinson's psychosis patients, mean age ± SD = 67.92 ± 4.37 years; 51.36% males; 853 Parkinson's patients, mean age ± SD = 66.75 ± 4.19 years; 55.81% males). Qualitative synthesis revealed widespread patterns of altered brain function across task-based and resting-state functional MRI studies in Parkinson's psychosis patients compared with Parkinson's patients without psychosis. Similarly, white matter abnormalities were reported in parietal, temporal and occipital regions. Hypo-metabolism and reduced dopamine transporter binding were also reported whole brain and in sub-cortical areas. This suggests extensive alterations affecting regions involved in high-order visual processing and attentional networks.
UR - http://www.scopus.com/inward/record.url?scp=85208712626&partnerID=8YFLogxK
U2 - 10.1093/braincomms/fcae358
DO - 10.1093/braincomms/fcae358
M3 - Review article
C2 - 39507273
SN - 2632-1297
VL - 6
SP - fcae358
JO - Brain Communications
JF - Brain Communications
IS - 6
M1 - fcae358
ER -