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Functional and hybrid imaging of bone metastases

Research output: Contribution to journalReview article

Original languageEnglish
JournalJournal of Bone and Mineral Research
Issue number6
Early online date23 May 2018
Accepted/In press6 Apr 2018
E-pub ahead of print23 May 2018
PublishedJun 2018


King's Authors


Bone metastases are common, cause significant morbidity and impact on healthcare resources. While radiographs, computed tomography (CT), magnetic resonance imaging (MRI) and bone scintigraphy have frequently been used for staging the skeleton, it is recognized that these methods are insensitive and non-specific for monitoring treatment response in a clinically relevant time frame.
We summarize several recent reports on new functional and hybrid imaging methods including single photon emission CT / CT, positron emission tomography / CT and whole-body MRI with diffusion-weighted imaging.
These modalities generally show improvements in diagnostic accuracy for staging and response assessment over standard imaging methods, with the ability to quantify biological processes related to the bone microenvironment as well as tumor cells.
As some of these methods are now being adopted into routine clinical practice and clinical trials, further evaluation with comparative studies are still required to guide optimal and cost effective clinical management of patients with skeletal metastases.

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