Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

G. B. Rogers*, J. Kozlowska, J. Keeble, K. Metcalfe, M. Fao, S. E. Dowd, A. J. Mason, M. A. McGuckin, K. D. Bruce

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)
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Abstract

Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.

Original languageEnglish
Article number5437
Number of pages5
JournalScientific Reports
Volume4
Early online date25 Jun 2014
DOIs
Publication statusPublished - 2015

Keywords

  • AMPLICON PYROSEQUENCING BTEFAP
  • GUT MICROBIOTA
  • BACTERIAL DIVERSITY
  • COLONIC MICROBIOTA
  • OBESITY
  • METABOLOMICS
  • BEHAVIOR
  • HEALTH
  • CANCER
  • DIET

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