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Functional dyspepsia in depression: A population-based cohort study

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Kai Liang Kao, Fung Chang Sung, Hui Chun Huang, Chen Ju Lin, Shu Chin Chen, Cheng Li Lin, Yo Ping Huang, Shu I. Wu, Yi Shin Chen, Robert Stewart

Original languageEnglish
Article numbere13506
JournalEuropean Journal of Clinical Investigation
Volume51
Issue number6
DOIs
Accepted/In press2021
PublishedJun 2021

Bibliographical note

Funding Information: This study is supported in part by Taiwan Ministry of Health and Welfare Clinical Trial Center (MOHW109‐TDU‐B‐212‐114004), MOST Clinical Trial Consortium for Stroke (MOST Clinical Trial Consortium for Stroke (MOST 109‐2321‐B‐039‐002), Tseng‐Lien Lin Foundation, Taichung, Taiwan. Department of Research, Mackay Memorial Hospital (MMH‐109112, MMH‐10914, MMH‐108121, MMH‐108146, MMH‐TT‐10804 (NTUT‐MMH‐108‐04, MMH‐TH‐10804). RS is part‐funded by: i) the National Institute for Health Research (NIHR) Biomedical Research Centre at the South London and Maudsley NHS Foundation Trust and King’s College London; ii) an NIHR Senior Investigator Award; iii) the National Institute for Health Research (NIHR) Applied Research Collaboration South London (NIHR ARC South London) at King’s College Hospital NHS Foundation Trust. Funding Information: This study is supported in part by Taiwan Ministry of Health and Welfare Clinical Trial Center (MOHW109-TDU-B-212-114004), MOST Clinical Trial Consortium for Stroke (MOST Clinical Trial Consortium for Stroke (MOST 109-2321-B-039-002), Tseng-Lien Lin Foundation, Taichung, Taiwan. Department of Research, Mackay Memorial Hospital (MMH-109112, MMH-10914, MMH-108121, MMH-108146, MMH-TT-10804 (NTUT-MMH-108-04, MMH-TH-10804). RS is part-funded by: i) the National Institute for Health Research (NIHR) Biomedical Research Centre at the South London and Maudsley NHS Foundation Trust and King?s College London; ii) an NIHR Senior Investigator Award; iii) the National Institute for Health Research (NIHR) Applied Research Collaboration South London (NIHR ARC South London) at King?s College Hospital NHS Foundation Trust. Publisher Copyright: © 2021 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors

Abstract

Background: Patients with functional dyspepsia (FD) are more likely to have persistent depression, yet whether depression and antidepressant treatments are associated with subsequent risk of FD remain unclear. Methods: Using population-based insurance administrative data of Taiwan, an 11-year historic cohort study was assembled, comparing cases aged 18 and above with the diagnosis of depressive disorder, to a propensity score-matched sample of adults without depression. Incident FD as a primary diagnosis was ascertained. Hazard ratios of FD were calculated using Cox regression models by age, gender, other comorbidities, nonsteroidal anti-inflammatory medications, antidepressants and antidiabetic agents. Results: A total of 20,197 people with depressive disorder and 20,197 propensity score-matched comparisons without depression were followed up. The incidence of FD was 1.7-fold greater in the depressive cohort than in comparisons (12.9 versus 7.57 per 1000 person-years), with an adjusted hazard ratio (aHR) of 2.16 (95% confidence interval (CI) 1.93~2.41). Increased risks were significant regardless of comorbidities or medication uses, the highest in the untreated depression group compared to the group without depression, with an aHR of 2.51(95% CI 2.15~2.93). Conclusions: This population-based study showed that patients with depressive disorder are at elevated risk of FD. Antidepressant treatment could reduce the risk of FD.

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