King's College London

Research portal

Functional genomics and the future of iPSCs in disease modeling

Research output: Contribution to journalReview articlepeer-review

Original languageEnglish
Pages (from-to)1033-1047
Number of pages15
JournalStem cell reports
Volume17
Issue number5
Early online date13 Apr 2022
DOIs
E-pub ahead of print13 Apr 2022
Published10 May 2022

Bibliographical note

Funding Information: Our apologies go to all authors whose important work could not be mentioned due to space limitations. We gratefully acknowledge the financial support of the Wellcome Trust PhD program Advanced Therapies for Regenerative Medicine ( 218461/Z/19/Z ). We thank Dr. Fay Minty for her support of the program. Publisher Copyright: © 2022

King's Authors

Abstract

Induced pluripotent stem cells (iPSCs) are valuable in disease modeling because of their potential to expand and differentiate into virtually any cell type and recapitulate key aspects of human biology. Functional genomics are genome-wide studies that aim to discover genotype-phenotype relationships, thereby revealing the impact of human genetic diversity on normal and pathophysiology. In this review, we make the case that human iPSCs (hiPSCs) are a powerful tool for functional genomics, since they provide an in vitro platform for the study of population genetics. We describe cutting-edge tools and strategies now available to researchers, including multi-omics technologies, advances in hiPSC culture techniques, and innovations in drug development. Functional genomics approaches based on hiPSCs hold great promise for advancing drug discovery, disease etiology, and the impact of genetic variation on human biology.

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454