Functional imaging techniques in hepatocellular carcinoma

TY - JOUR

T1 - Functional imaging techniques in hepatocellular carcinoma

AU - Goh, V

AU - Sarker, D

AU - Osmany, S

AU - Cook, G J R

PY - 2012/6

Y1 - 2012/6

N2 - Novel biological therapies, including tyrosine kinase inhibitors such as sorafenib, improve the survival of patients with unresectable hepatocellular carcinoma. However, assessment of therapeutic efficacy remains challenging with conventional imaging techniques such as ultrasonography, CT or MRI that predominantly rely on size change to detect a treatment response. A beneficial tumour effect may go unrecognized in some patients who do not show tumour shrinkage and conversely, some patients may be maintained on treatment that is not active. This paper explores the use of functional imaging methods that are showing promise in the assessment of hepatocellular carcinoma.

AB - Novel biological therapies, including tyrosine kinase inhibitors such as sorafenib, improve the survival of patients with unresectable hepatocellular carcinoma. However, assessment of therapeutic efficacy remains challenging with conventional imaging techniques such as ultrasonography, CT or MRI that predominantly rely on size change to detect a treatment response. A beneficial tumour effect may go unrecognized in some patients who do not show tumour shrinkage and conversely, some patients may be maintained on treatment that is not active. This paper explores the use of functional imaging methods that are showing promise in the assessment of hepatocellular carcinoma.

U2 - 10.1007/s00259-012-2096-x

DO - 10.1007/s00259-012-2096-x

M3 - Article

C2 - 22434049

SN - 1619-7089

VL - 39

SP - 1070

EP - 1079

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 6

ER -