Functional magnetic resonance imaging of the acute effect of intravenous heroin administration on visual activation in long-term heroin addicts: results from a feasibility study

TY - JOUR

T1 - Functional magnetic resonance imaging of the acute effect of intravenous heroin administration on visual activation in long-term heroin addicts

T2 - results from a feasibility study

AU - Sell, L A

AU - Simmons, A

AU - Lemmens, G M

AU - Williams, S C

AU - Brammer, M

AU - Strang, J

PY - 1997/12/30

Y1 - 1997/12/30

N2 - This preliminary report is the first demonstration of the acute effects of diacetylmorphine (heroin) administration on functional activation in the human brain using functional magnetic resonance imaging (fMRI). Four opiate addicts who received regular prescriptions for heroin, underwent fMRI using a visual activation paradigm before and after a dose of 30 mg heroin. All four showed a decrease after the heroin dose in the extent of significant activation. This method shows promise for sequential scanning to determine brain activity in response to different drugs and routes of drug administration.

AB - This preliminary report is the first demonstration of the acute effects of diacetylmorphine (heroin) administration on functional activation in the human brain using functional magnetic resonance imaging (fMRI). Four opiate addicts who received regular prescriptions for heroin, underwent fMRI using a visual activation paradigm before and after a dose of 30 mg heroin. All four showed a decrease after the heroin dose in the extent of significant activation. This method shows promise for sequential scanning to determine brain activity in response to different drugs and routes of drug administration.

U2 - 10.1016/S0376-8716(97)00140-3

DO - 10.1016/S0376-8716(97)00140-3

M3 - Article

C2 - 9476700

SN - 0376-8716

VL - 49

SP - 55

EP - 60

JO - Drug and alcohol dependence

JF - Drug and alcohol dependence

IS - 1

ER -