Functional Neuroimaging Predictors of Self-Reported Psychotic Symptoms in Adolescents

Josiane Bourque, Philip A. Spechler, Stéphane Potvin, Robert Whelan, Tobias Banaschewski, Arun L W Bokde, Uli Bromberg, Christian Buechel, Erin Burke Quinlan, Sylvane Desrivieres, Herta Flor, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère-Martinot, Sarah C. McEwen, Frauke Nees, Dimitri Papadopoulos OrfanosTomáš Paus, Luise Poustka, Michael N. Smolka, Nora C. Vetter, Henrik Walter, Gunter Schumann, Hugh Garavan, Patricia J. Conrod, IMAGEN Consortium

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)
48 Downloads (Pure)

Abstract

Objective:
This study investigated the neural correlates of psychotic-like experiences in youths during tasks involving inhibitory control, reward anticipation, and emotion processing. A secondary aim was to test whether these neurofunctional correlates of risk were predictive of psychotic symptoms 2 years later.

Method:
Functional imaging responses to three paradigms—the stop-signal, monetary incentive delay, and faces tasks—were collected in youths at age 14, as part of the IMAGEN study. At baseline, youths from London and Dublin sites were assessed on psychotic-like experiences, and those reporting significant experiences were compared with matched control subjects. Significant brain activity differences between the groups were used to predict, with cross-validation, the presence of psychotic symptoms in the context of mood fluctuation at age 16, assessed in the full sample. These prediction analyses were conducted with the London-Dublin subsample (N=246) and the full sample (N=1,196).

Results:
Relative to control subjects, youths reporting psychotic-like experiences showed increased hippocampus/amygdala activity during processing of neutral faces and reduced dorsolateral prefrontal activity during failed inhibition. The most prominent regional difference for classifying 16-year-olds with mood fluctuation and psychotic symptoms relative to the control groups (those with mood fluctuations but no psychotic symptoms and those with no mood symptoms) was hyperactivation of the hippocampus/amygdala, when controlling for baseline psychotic-like experiences and cannabis use.

Conclusions:
The results stress the importance of the limbic network’s increased response to neutral facial stimuli as a marker of the extended psychosis phenotype. These findings might help to guide early intervention strategies for at-risk youths.
Original languageEnglish
Pages (from-to)566-575
JournalThe American Journal of Psychiatry
Volume147
Issue number6
Early online date21 Mar 2017
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • Adolescents
  • Brain Imaging Techniques
  • Mood Disorders-Bipolar
  • Psychosis

Fingerprint

Dive into the research topics of 'Functional Neuroimaging Predictors of Self-Reported Psychotic Symptoms in Adolescents'. Together they form a unique fingerprint.

Cite this