King's College London

Research portal

Functional reorganisation and recovery following cortical lesions: A preliminary study in macaque monkeys

Research output: Contribution to journalArticlepeer-review

Matthew Ainsworth, Helen Browncross, Daniel J. Mitchell, Anna S. Mitchell, Richard E. Passingham, Mark J. Buckley, John Duncan, Andrew H. Bell

Original languageEnglish
Pages (from-to)382-391
Number of pages10
Early online date12 Sep 2018
Accepted/In press27 Aug 2018
E-pub ahead of print12 Sep 2018
PublishedOct 2018

Bibliographical note

Funding Information: This work was supported by the Medical Research Council (MRC) intramural program ( SUAG/002/RG91365 , to MA, DM, JD, and AB) and a Medical Research Council Career Development Award ( G0800329 , AM). The authors thank Jerome Sallet, Matthew F Rushworth, Richard N Henson for advice on connectivity analysis; Subhojit Chakraborty with data collection; Stuart Mason for training the animals, and the Oxford Biomedical Sciences Staff for their assistance with the animals. Publisher Copyright: © 2018 The Author(s) Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

King's Authors


Damage following traumatic brain injury or stroke can often extend beyond the boundaries of the initial insult and can lead to maladaptive cortical reorganisation. On the other hand, beneficial cortical reorganisation leading to recovery of function can also occur. We used resting state FMRI to investigate how cortical networks in the macaque brain change across time in response to lesions to the prefrontal cortex, and how this reorganisation correlated with changes in behavioural performance in cognitive tasks. After prelesion testing and scanning, two monkeys received a lesion to regions surrounding the left principal sulcus followed by periodic testing and scanning. Later, the animals received another lesion to the opposite hemisphere and additional testing and scanning. Following the first lesion, we observed both a behavioural impairment and decrease in functional connectivity, predominantly in frontal-frontal networks. Approximately 8 weeks later, performance and connectivity patterns both improved. Following the second lesion, we observed a further behavioural deficit and decrease in connectivity that showed little recovery. We discuss how different mechanisms including alternate behavioural strategies and reorganisation of specific prefrontal networks may have led to improvements in behaviour. Further work will be needed to confirm these mechanisms.

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454