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Functionalization of filled radioactive multi-walled carbon nanocapsules by arylation reaction forin vivodelivery of radio-therapy

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Agnieszka Gajewska, Julie T.W. Wang, Rebecca Klippstein, Markus Martincic, Elzbieta Pach, Robert Feldman, Jean Claude Saccavini, Gerard Tobias, Belén Ballesteros, Khuloud T. Al-Jamal, Tatiana Da Ros

Original languageEnglish
Pages (from-to)47-56
Number of pages10
JournalJournal of materials chemistry b
Volume10
Issue number1
DOIs
Published7 Jan 2022

Bibliographical note

Funding Information: We thank Thomas Swan & Co. Ltd for supplying the Eli-carb? MWCNTs. This work was supported by European Union's Seventh Framework Programme FP7, Project ?RADDEL? [grant number 290023], Worldwide Cancer Research [grant number 12-1054], Biotechnology and Biological Sciences Research Council [grant number BB/J008656/1], European Union HORIZON 2020 MSCA RISE 2016, Project Carbo-Immap [grant number 734381], ?Severo Ochoa? Programme for Centres of Excellence in R&D [grant numbers SEV-2015-0496, SEV-2017-0706], and Generalitat de Catalunya 2017 [grant number SGR 327]. Funding Information: We thank Thomas Swan & Co. Ltd for supplying the Eli-carbs MWCNTs. This work was supported by European Union’s Seventh Framework Programme FP7, Project ‘‘RADDEL’’ [grant number 290023], Worldwide Cancer Research [grant number 12-1054], Biotechnology and Biological Sciences Research Council [grant number BB/J008656/1], European Union HORIZON 2020 MSCA RISE 2016, Project Carbo-Immap [grant number 734381], ‘‘Severo Ochoa’’ Programme for Centres of Excellence in R&D [grant numbers SEV-2015-0496, SEV-2017-0706], and Generalitat de Catalunya 2017 [grant number SGR 327]. Publisher Copyright: © The Royal Society of Chemistry 2021.

King's Authors

Abstract

Functionalized multi-walled carbon nanotubes (MWCNTs) containing radioactive salts are proposed as a potential system for radioactivity delivery. MWCNTs are loaded with isotopically enriched 152-samarium chloride (152SmCl3), the ends of the MWCNTs are sealed by high temperature treatment, and the encapsulated152Sm is neutron activated to radioactive153Sm. The external walls of the radioactive nanocapsules are functionalized through arylation reaction, to introduce hydrophilic chains and increase the water dispersibility of CNTs. The organ biodistribution profiles of the nanocapsules up to 24 h are assessed in naïve mice and different tumor modelsin vivo. By quantitative γ-counting,153SmCl3@MWCNTs-NH2exhibite high accumulation in organs without leakage of the internal radioactive material to the bloodstream. In the treated mice, highest uptake is detected in the lung followed by the liver and spleen. Presence of tumors in brain or lung does not increase percentage accumulation of153SmCl3@MWCNTs-NH2in the respective organs, suggesting the absence of the enhanced permeation and retention effect. This study presents a chemical functionalization protocol that is rapid (∼one hour) and can be applied to filled radioactive multi-walled carbon nanocapsules to improve their water dispersibility for systemic administration for their use in targeted radiotherapy.

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