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Fungal toxins and host immune responses

Research output: Contribution to journalReview articlepeer-review

Original languageEnglish
Article number643639
JournalFrontiers in microbiology
Early online date13 Apr 2021
Accepted/In press8 Mar 2021
E-pub ahead of print13 Apr 2021
Published13 Apr 2021

Bibliographical note

Funding Information: Funding. This work was supported by grants from the Wellcome Trust (214229_Z_18_Z), Biotechnology & Biological Sciences Research Council (BB/N014677/1), National Institutes of Health (R37-DE022550), the NIH Research at Guys and St. Thomas?s NHS Foundation Trust and the King?s College London Biomedical Research Centre (IS-BRC-1215-20006), and a Faculty of Dentistry, Oral & Craniofacial Sciences (FoDOCS) Ph.D. studentship. Publisher Copyright: © Copyright © 2021 Brown, Priest, Naglik and Richardson. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.


King's Authors


Fungi are ubiquitous organisms that thrive in diverse natural environments including soils, plants, animals, and the human body. In response to warmth, humidity, and moisture, certain fungi which grow on crops and harvested foodstuffs can produce mycotoxins; secondary metabolites which when ingested have a deleterious impact on health. Ongoing research indicates that some mycotoxins and, more recently, peptide toxins are also produced during active fungal infection in humans and experimental models. A combination of innate and adaptive immune recognition allows the host to eliminate invading pathogens from the body. However, imbalances in immune homeostasis often facilitate microbial infection. Despite the wide-ranging effects of fungal toxins on health, our understanding of toxin-mediated modulation of immune responses is incomplete. This review will explore the current understanding of fungal toxins and how they contribute to the modulation of host immunity.

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