G-CSF enables completion of tuberculosis therapy associated with iatrogenic neutropenia

TY - JOUR

T1 - G-CSF enables completion of tuberculosis therapy associated with iatrogenic neutropenia

AU - Cormican, L J

AU - Schey, S

AU - Milburn, H J

PY - 2004/4

Y1 - 2004/4

N2 - Neutropenia is a rare complication of anti-tuberculous therapy and is usually due to a single agent, most frequently isoniazid. The current case describes a previously healthy immunocompetent patient with tuberculosis of the lymph nodes who developed neutropenia due to a number of first line antibiotics (rifampicin, isoniazid and ethambutol) and streptomycin when introduced in combination and individually thus resulting in repeated treatment disruption. The introduction of twice-weekly subcutaneous granulocyte-colony stimulating factor to correct iatrogenic neutropenia facilitated the continuation and eventual completion of therapy without adverse effect. This is the first description of the use of granulocyte-colony stimulating factor to correct iatrogenic neutropenia due to anti-tuberculous antibiotics and the second description of the occurrence of iatrogenic neutropenia to more than anti-tuberculous antibiotic in an individual.

AB - Neutropenia is a rare complication of anti-tuberculous therapy and is usually due to a single agent, most frequently isoniazid. The current case describes a previously healthy immunocompetent patient with tuberculosis of the lymph nodes who developed neutropenia due to a number of first line antibiotics (rifampicin, isoniazid and ethambutol) and streptomycin when introduced in combination and individually thus resulting in repeated treatment disruption. The introduction of twice-weekly subcutaneous granulocyte-colony stimulating factor to correct iatrogenic neutropenia facilitated the continuation and eventual completion of therapy without adverse effect. This is the first description of the use of granulocyte-colony stimulating factor to correct iatrogenic neutropenia due to anti-tuberculous antibiotics and the second description of the occurrence of iatrogenic neutropenia to more than anti-tuberculous antibiotic in an individual.

UR - http://www.scopus.com/inward/record.url?scp=1842585670&partnerID=8YFLogxK

U2 - 10.1183/09031936.04.00053804

DO - 10.1183/09031936.04.00053804

M3 - Article

SN - 1399-3003

VL - 23

SP - 649

EP - 650

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 4

ER -