GABA system dysfunction in autism and related disorders: from synapse to symptoms

Suzanne Coghlan; Jamie Horder; Becky Inkster; M. Andreina Mendez; Declan G. Murphy; David J. Nutt

doi:10.1016/j.neubiorev.2012.07.005

GABA system dysfunction in autism and related disorders: from synapse to symptoms

Suzanne Coghlan, Jamie Horder, Becky Inkster, M. Andreina Mendez, Declan G. Murphy, David J. Nutt

Research output: Contribution to journal › Literature review › peer-review

345 Citations (Scopus)

Abstract

Autism spectrum disorders (ASDs) are neurodevelopmental syndromes characterised by repetitive behaviours and restricted interests, impairments in social behaviour and relations, and in language and communication. These symptoms are also observed in a number of developmental disorders of known origin, including Fragile X Syndrome, Rett Syndrome, and Foetal Anticonvulsant Syndrome. While these conditions have diverse etiologies, and poorly understood pathologies, emerging evidence suggests that they may all be linked to dysfunction in particular aspects of GABAergic inhibitory signalling in the brain. We review evidence from genetics, molecular neurobiology and systems neuroscience relating to the role of GABA in these conditions. We conclude by discussing how these deficits may relate to the specific symptoms observed.

Original language	English
Article number	N/A
Pages (from-to)	2044-2055
Number of pages	12
Journal	Neuroscience and Biobehavioral Reviews
Volume	36
Issue number	9
DOIs	https://doi.org/10.1016/j.neubiorev.2012.07.005
Publication status	Published - Oct 2012

Keywords

Brain
Child
Child Development Disorders, Pervasive
Fragile X Syndrome
GABAergic Neurons
Humans
Neurons
Rett Syndrome
Synapses
gamma-Aminobutyric Acid

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10.1016/j.neubiorev.2012.07.005

Cite this

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title = "GABA system dysfunction in autism and related disorders: from synapse to symptoms",

abstract = "Autism spectrum disorders (ASDs) are neurodevelopmental syndromes characterised by repetitive behaviours and restricted interests, impairments in social behaviour and relations, and in language and communication. These symptoms are also observed in a number of developmental disorders of known origin, including Fragile X Syndrome, Rett Syndrome, and Foetal Anticonvulsant Syndrome. While these conditions have diverse etiologies, and poorly understood pathologies, emerging evidence suggests that they may all be linked to dysfunction in particular aspects of GABAergic inhibitory signalling in the brain. We review evidence from genetics, molecular neurobiology and systems neuroscience relating to the role of GABA in these conditions. We conclude by discussing how these deficits may relate to the specific symptoms observed.",

keywords = "Brain, Child, Child Development Disorders, Pervasive, Fragile X Syndrome, GABAergic Neurons, Humans, Neurons, Rett Syndrome, Synapses, gamma-Aminobutyric Acid",

author = "Suzanne Coghlan and Jamie Horder and Becky Inkster and Mendez, {M. Andreina} and Murphy, {Declan G.} and Nutt, {David J.}",

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journal = "Neuroscience and Biobehavioral Reviews",

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T1 - GABA system dysfunction in autism and related disorders

T2 - from synapse to symptoms

AU - Coghlan, Suzanne

AU - Horder, Jamie

AU - Inkster, Becky

AU - Mendez, M. Andreina

AU - Murphy, Declan G.

AU - Nutt, David J.

PY - 2012/10

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N2 - Autism spectrum disorders (ASDs) are neurodevelopmental syndromes characterised by repetitive behaviours and restricted interests, impairments in social behaviour and relations, and in language and communication. These symptoms are also observed in a number of developmental disorders of known origin, including Fragile X Syndrome, Rett Syndrome, and Foetal Anticonvulsant Syndrome. While these conditions have diverse etiologies, and poorly understood pathologies, emerging evidence suggests that they may all be linked to dysfunction in particular aspects of GABAergic inhibitory signalling in the brain. We review evidence from genetics, molecular neurobiology and systems neuroscience relating to the role of GABA in these conditions. We conclude by discussing how these deficits may relate to the specific symptoms observed.

AB - Autism spectrum disorders (ASDs) are neurodevelopmental syndromes characterised by repetitive behaviours and restricted interests, impairments in social behaviour and relations, and in language and communication. These symptoms are also observed in a number of developmental disorders of known origin, including Fragile X Syndrome, Rett Syndrome, and Foetal Anticonvulsant Syndrome. While these conditions have diverse etiologies, and poorly understood pathologies, emerging evidence suggests that they may all be linked to dysfunction in particular aspects of GABAergic inhibitory signalling in the brain. We review evidence from genetics, molecular neurobiology and systems neuroscience relating to the role of GABA in these conditions. We conclude by discussing how these deficits may relate to the specific symptoms observed.

KW - Brain

KW - Child

KW - Child Development Disorders, Pervasive

KW - Fragile X Syndrome

KW - GABAergic Neurons

KW - Humans

KW - Neurons

KW - Rett Syndrome

KW - Synapses

KW - gamma-Aminobutyric Acid

U2 - 10.1016/j.neubiorev.2012.07.005

DO - 10.1016/j.neubiorev.2012.07.005

M3 - Literature review

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ER -

GABA system dysfunction in autism and related disorders: from synapse to symptoms

Abstract

Keywords

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