Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging

Hongguang Li; Bethany I Harriss; Alkystis Phinikaridou; Sara Lacerda; Gregory Ramniceanu; Bich-Thuy Doan; Ka-Lok Ho; Chi-Fai Chan; Wai-Sum Lo; René M Botnar; Rongfeng Lan; Cyrille Richard; Ga-Lai Law; Nicholas J Long; Ka-Leung Wong

doi:10.7150/ntno.18619

Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging

Hongguang Li, Bethany I Harriss, Alkystis Phinikaridou, Sara Lacerda, Gregory Ramniceanu, Bich-Thuy Doan, Ka-Lok Ho, Chi-Fai Chan, Wai-Sum Lo, René M Botnar, Rongfeng Lan, Cyrille Richard, Ga-Lai Law, Nicholas J Long, Ka-Leung Wong

Biomedical Engineering Department

Hong Kong Baptist University
Imperial College London
PET Imaging Centre, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, 1st Floor, Lambeth Wing, London, SE1 7EH, United Kingdom.
Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS); CNRS UMR 8258; Inserm U 1022; Université Paris Descartes, Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France.
Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR.

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192 Downloads (Pure)

Abstract

A novel dual-imaging cisplatin-carrying molecular cargo capable of performing simultaneous optical and MR imaging is reported herein. This long-lasting MRI contrast agent (r1 relaxivity of 23.4 mM(-1)s(-1) at 3T, 25 (o)C) is a photo-activated cisplatin prodrug (PtGdL) which enables real-time monitoring of anti-cancer efficacy. PtGdL is a model for monitoring the drug delivery and anti-cancer efficacy by MRI with a much longer retention time (24 hours) in several organs such as renal cortex and spleen than GdDOTA and its motif control GdL. Upon complete release of cisplatin, all PtGdL is converted to GdL enabling subsequent MRI analyses of therapy efficacy within its reasonably short clearance time of 4 hours. There is also responsive fluorescence enhancement for monitoring by photon-excitation.

Original language	English
Pages (from-to)	186-195
Number of pages	10
Journal	Nanotheranostics
Volume	1
Issue number	2
Early online date	8 May 2017
DOIs	https://doi.org/10.7150/ntno.18619
Publication status	E-pub ahead of print - 8 May 2017

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10.7150/ntno.18619Licence: CC BY-NC

Gadolinium and Platinum in_LI_Publishedonline8May2017_GREEN VoR (CC BY-NC)Final published version, 1.32 MBLicence: CC BY-NC

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Li, H., Harriss, B. I., Phinikaridou, A., Lacerda, S., Ramniceanu, G., Doan, B.-T., Ho, K.-L., Chan, C.-F., Lo, W.-S., Botnar, R. M., Lan, R., Richard, C., Law, G.-L., Long, N. J., & Wong, K.-L. (2017). Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging. Nanotheranostics, 1(2), 186-195. Advance online publication. https://doi.org/10.7150/ntno.18619

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title = "Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging",

abstract = "A novel dual-imaging cisplatin-carrying molecular cargo capable of performing simultaneous optical and MR imaging is reported herein. This long-lasting MRI contrast agent (r1 relaxivity of 23.4 mM(-1)s(-1) at 3T, 25 (o)C) is a photo-activated cisplatin prodrug (PtGdL) which enables real-time monitoring of anti-cancer efficacy. PtGdL is a model for monitoring the drug delivery and anti-cancer efficacy by MRI with a much longer retention time (24 hours) in several organs such as renal cortex and spleen than GdDOTA and its motif control GdL. Upon complete release of cisplatin, all PtGdL is converted to GdL enabling subsequent MRI analyses of therapy efficacy within its reasonably short clearance time of 4 hours. There is also responsive fluorescence enhancement for monitoring by photon-excitation.",

author = "Hongguang Li and Harriss, {Bethany I} and Alkystis Phinikaridou and Sara Lacerda and Gregory Ramniceanu and Bich-Thuy Doan and Ka-Lok Ho and Chi-Fai Chan and Wai-Sum Lo and Botnar, {Ren{\'e} M} and Rongfeng Lan and Cyrille Richard and Ga-Lai Law and Long, {Nicholas J} and Ka-Leung Wong",

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month = may,

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doi = "10.7150/ntno.18619",

language = "English",

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Li, H, Harriss, BI, Phinikaridou, A, Lacerda, S, Ramniceanu, G, Doan, B-T, Ho, K-L, Chan, C-F, Lo, W-S, Botnar, RM, Lan, R, Richard, C, Law, G-L, Long, NJ & Wong, K-L 2017, 'Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging', Nanotheranostics, vol. 1, no. 2, pp. 186-195. https://doi.org/10.7150/ntno.18619

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AU - Li, Hongguang

AU - Harriss, Bethany I

AU - Phinikaridou, Alkystis

AU - Lacerda, Sara

AU - Ramniceanu, Gregory

AU - Doan, Bich-Thuy

AU - Ho, Ka-Lok

AU - Chan, Chi-Fai

AU - Lo, Wai-Sum

AU - Botnar, René M

AU - Lan, Rongfeng

AU - Richard, Cyrille

AU - Law, Ga-Lai

AU - Long, Nicholas J

AU - Wong, Ka-Leung

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ER -

Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging

Abstract

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