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GAPPS (Grading and Assessment of Pharmacokinetic-Pharmacodynamic Studies) a critical appraisal system for antimicrobial PKPD studies–development and application in pediatric antibiotic studies

Research output: Contribution to journalReview articlepeer-review

Silke Gastine, Asia N. Rashed, Yingfen Hsia, Charlotte Jackson, Charlotte I.S. Barker, Shrey Mathur, Stephen Tomlin, Irja Lutsar, Julia Bielicki, Joseph F. Standing, Mike Sharland

Original languageEnglish
Pages (from-to)1091-1098
Number of pages8
JournalExpert review of clinical pharmacology
Volume12
Issue number12
Early online date30 Nov 2019
DOIs
Accepted/In press18 Nov 2019
E-pub ahead of print30 Nov 2019
Published2019

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King's Authors

Abstract

Introduction: There are limited data on optimal dosing of antibiotics in different age groups for neonates and children. Clinicians usually consult pediatric formularies or online databases for dose selection, but these have variable recommendations, are usually based on expert opinion and are not graded based on the existing pharmacokinetic-pharmacodynamic (PKPD) studies. We describe here a potential new tool that could be used to grade the strength of evidence emanating from PKPD studies. Areas covered: A scoring system was developed (GAPPS tool) to quantify the strength of each PK assessment and rate the studies quality in already published articles. GAPPS was evaluated by applying it to pediatric PKPD studies of antibiotics from the 2019 Essential Medicines List for children (EMLC), identified through a search of PubMed. Expert opinion: Evidence for most antibiotic dose selection decisions was generally weak, coming from individual PK studies and lacked PKPD modeling and simulations. However, the quality of evidence appears to have improved over the last two decades. Incorporating a formal grading system, such as GAPPS, into formulary development will provide a transparent tool to support decision-making in clinical practice and guideline development, and guide PKPD authors on study designs most likely to influence guidelines.

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