Gastroesophageal reflux disease and sudden infant death: Mechanisms behind an under-recognized association

TY - JOUR

T1 - Gastroesophageal reflux disease and sudden infant death

T2 - Mechanisms behind an under-recognized association

AU - Al-Adnani, Mudher

AU - Cohen, Marta C.

AU - Scheimberg, Irene

PY - 2011/1

Y1 - 2011/1

N2 - We present 4 cases of sudden infant death in which we believe that gastroesophageal reflux (GOR) was a contributory, if not a causative, factor. Two of our patients had documented GOR reflux disease during life, and all 4 cases showed histologic evidence of GOR. No other cause of death was identified in any of the patients. Gastroesophageal reflux can cause sudden death in a vulnerable infant during a critical period of development through failure of "autoresuscitation" mechanisms.

AB - We present 4 cases of sudden infant death in which we believe that gastroesophageal reflux (GOR) was a contributory, if not a causative, factor. Two of our patients had documented GOR reflux disease during life, and all 4 cases showed histologic evidence of GOR. No other cause of death was identified in any of the patients. Gastroesophageal reflux can cause sudden death in a vulnerable infant during a critical period of development through failure of "autoresuscitation" mechanisms.

KW - Gastroesophageal reflux

KW - Sudden infant death

UR - http://www.scopus.com/inward/record.url?scp=79955042586&partnerID=8YFLogxK

U2 - 10.2350/09-11-0748-CR.1

DO - 10.2350/09-11-0748-CR.1

M3 - Article

C2 - 20429661

AN - SCOPUS:79955042586

SN - 1093-5266

VL - 14

SP - 53

EP - 56

JO - PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

JF - PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

IS - 1

ER -