TY - JOUR
T1 - Gastrointestinal symptoms, gut microbiome, probiotics and prebiotics in Anorexia Nervosa
T2 - a review of mechanistic rationale and clinical evidence
AU - Dhopatkar, Namrata
AU - Keeler, Johanna Louise
AU - Mutwalli, Hiba
AU - Whelan, Kevin
AU - Treasure, Janet
AU - Himmerich, Hubertus
N1 - Funding Information:
N.D. was supported by research funding from South London and Maudsley NHS FoundationTrust ( SlaM ). J.K. received a PhD stipend from the Medical Research Council (reference no.: MR/N013700/1 ). H.M. received funding from the Saudi Scholarship Scheme for Higher Education . K.W. received salary support from Kings College London ( KCL ). J.T. is part funded by the National Institute for Health Research (NIHR) and Mental Health Biomedical Research Centre at SLaM and KCL. H.H. received salary support from the NIHR Biomedical Research Centre (BRC) at SLaM and KCL.
Funding Information:
N.D. was supported by research funding from South London and Maudsley NHS FoundationTrust (SlaM). J.K. received a PhD stipend from the Medical Research Council (reference no.: MR/N013700/1). H.M. received funding from the Saudi Scholarship Scheme for Higher Education. K.W. received salary support from Kings College London (KCL). J.T. is part funded by the National Institute for Health Research (NIHR) and Mental Health Biomedical Research Centre at SLaM and KCL. H.H. received salary support from the NIHR Biomedical Research Centre (BRC) at SLaM and KCL. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.
Publisher Copyright:
© 2022 The Authors
PY - 2023/1
Y1 - 2023/1
N2 - Recent research has revealed the pivotal role that the gut microbiota might play in psychiatric disorders. In anorexia nervosa (AN), the gut microbiota may be involved in pathophysiology as well as in the gastrointestinal (GI) symptoms commonly experienced. This review collates evidence for the potential role of gut microbiota in AN, including modulation of the immune system, the gut-brain axis and GI function. We examined studies comparing gut microbiota in AN with healthy controls as well as those looking at modifications in gut microbiota with nutritional treatment. Changes in energy intake and nutritional composition influence gut microbiota and may play a role in the evolution of the gut microbial picture in AN. Additionally, some evidence indicates that pre-morbid gut microbiota may influence risk of developing AN. There appear to be similarities in gut microbial composition, mechanisms of interaction and GI symptoms experienced in AN and other GI disorders such as inflammatory bowel disease and functional GI disorders. Probiotics and prebiotics have been studied in these disorders showing therapeutic effects of probiotics in some cases. Additionally, some evidence exists for the therapeutic benefits of probiotics in depression and anxiety, commonly seen as co-morbidities in AN. Moreover, preliminary evidence for the use of probiotics in AN has shown positive effects on immune modulation. Based on these findings, we discuss the potential therapeutic role for probiotics in ameliorating symptoms in AN.
AB - Recent research has revealed the pivotal role that the gut microbiota might play in psychiatric disorders. In anorexia nervosa (AN), the gut microbiota may be involved in pathophysiology as well as in the gastrointestinal (GI) symptoms commonly experienced. This review collates evidence for the potential role of gut microbiota in AN, including modulation of the immune system, the gut-brain axis and GI function. We examined studies comparing gut microbiota in AN with healthy controls as well as those looking at modifications in gut microbiota with nutritional treatment. Changes in energy intake and nutritional composition influence gut microbiota and may play a role in the evolution of the gut microbial picture in AN. Additionally, some evidence indicates that pre-morbid gut microbiota may influence risk of developing AN. There appear to be similarities in gut microbial composition, mechanisms of interaction and GI symptoms experienced in AN and other GI disorders such as inflammatory bowel disease and functional GI disorders. Probiotics and prebiotics have been studied in these disorders showing therapeutic effects of probiotics in some cases. Additionally, some evidence exists for the therapeutic benefits of probiotics in depression and anxiety, commonly seen as co-morbidities in AN. Moreover, preliminary evidence for the use of probiotics in AN has shown positive effects on immune modulation. Based on these findings, we discuss the potential therapeutic role for probiotics in ameliorating symptoms in AN.
UR - http://www.scopus.com/inward/record.url?scp=85140628518&partnerID=8YFLogxK
U2 - 10.1016/j.psyneuen.2022.105959
DO - 10.1016/j.psyneuen.2022.105959
M3 - Review article
SN - 0306-4530
VL - 147
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
M1 - 105959
ER -