Gd³⁺ cFLFLFK conjugate for MRI: A targeted contrast agent for FPR1 in inflammation

TY - JOUR

T1 - Gd3+ cFLFLFK conjugate for MRI

T2 - A targeted contrast agent for FPR1 in inflammation

AU - Stasiuk, Graeme J.

AU - Smith, Helen

AU - Wylezinska-Arridge, Marzena

AU - Tremoleda, Jordi L.

AU - Trigg, William

AU - Luthra, Sajinder Kaur

AU - Iveson, Veronique Morisson

AU - Gavins, Felicity N.E.

AU - Long, Nicholas J.

PY - 2013/1/21

Y1 - 2013/1/21

N2 - Formyl Peptide Receptors (FPRs) are vital in the host inflammatory response, playing an important regulatory role in multiple diseases. A Gd(iii) DOTA conjugate of cFLFLFK has been synthesised which targets and visualises FPR1 upon leukocytes in the inflammatory response via magnetic resonance imaging for the first time.

AB - Formyl Peptide Receptors (FPRs) are vital in the host inflammatory response, playing an important regulatory role in multiple diseases. A Gd(iii) DOTA conjugate of cFLFLFK has been synthesised which targets and visualises FPR1 upon leukocytes in the inflammatory response via magnetic resonance imaging for the first time.

UR - http://www.scopus.com/inward/record.url?scp=84871306301&partnerID=8YFLogxK

U2 - 10.1039/c2cc37460a

DO - 10.1039/c2cc37460a

M3 - Article

C2 - 23208551

AN - SCOPUS:84871306301

SN - 1359-7345

VL - 49

SP - 564

EP - 566

JO - Chemical Communications

JF - Chemical Communications

IS - 6

ER -