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Gender differences in clinical presentation and illicit substance use during first episode psychosis: a natural language processing, electronic case register study

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Gender differences in clinical presentation and illicit substance use during first episode psychosis: a natural language processing, electronic case register study. / Irving, Jessica; Colling, Craig; Shetty, Hitesh et al.

In: BMJ Open, Vol. 11, No. 4, e042949, 21.04.2021.

Research output: Contribution to journalArticlepeer-review

Harvard

Irving, J, Colling, C, Shetty, H, Pritchard, M, Stewart, R, Fusar-Poli, P, McGuire, P & Patel, R 2021, 'Gender differences in clinical presentation and illicit substance use during first episode psychosis: a natural language processing, electronic case register study', BMJ Open, vol. 11, no. 4, e042949. https://doi.org/10.1136/bmjopen-2020-042949

APA

Irving, J., Colling, C., Shetty, H., Pritchard, M., Stewart, R., Fusar-Poli, P., McGuire, P., & Patel, R. (2021). Gender differences in clinical presentation and illicit substance use during first episode psychosis: a natural language processing, electronic case register study. BMJ Open, 11(4), [e042949]. https://doi.org/10.1136/bmjopen-2020-042949

Vancouver

Irving J, Colling C, Shetty H, Pritchard M, Stewart R, Fusar-Poli P et al. Gender differences in clinical presentation and illicit substance use during first episode psychosis: a natural language processing, electronic case register study. BMJ Open. 2021 Apr 21;11(4). e042949. https://doi.org/10.1136/bmjopen-2020-042949

Author

Irving, Jessica ; Colling, Craig ; Shetty, Hitesh et al. / Gender differences in clinical presentation and illicit substance use during first episode psychosis: a natural language processing, electronic case register study. In: BMJ Open. 2021 ; Vol. 11, No. 4.

Bibtex Download

@article{08d33a7098b24ffa97090aa06cc74f70,
title = "Gender differences in clinical presentation and illicit substance use during first episode psychosis: a natural language processing, electronic case register study",
abstract = "Objective To determine whether gender differences in symptom presentation at first episode psychosis (FEP) remain even when controlling for substance use, age and ethnicity, using natural language processing applied to electronic health records (EHRs). Design, setting and participants Data were extracted from EHRs of 3350 people (62% male patients) who had presented to the South London and Maudsley NHS Trust with a FEP between 1 April 2007 and 31 March 2017. Logistic regression was used to examine gender differences in the presentation of positive, negative, depressive, mania and disorganisation symptoms. Exposure(s) (for observational studies) Gender (male vs female). Main outcome(s) and measure(s) Presence of positive, negative, depressive, mania and disorganisation symptoms at initial clinical presentation. Results Eight symptoms were significantly more prevalent in men (poverty of thought, negative symptoms, social withdrawal, poverty of speech, aggression, grandiosity, paranoia and agitation). Conversely, tearfulness, low energy, reduced appetite, low mood, pressured speech, mood instability, flight of ideas, guilt, mutism, insomnia, poor concentration, tangentiality and elation were more prevalent in women than men. Negative symptoms were more common among men (OR 1.85, 95% CI 1.33 to 2.62) and depressive and manic symptoms more common among women (OR 0.30, 95% CI 0.26 to 0.35). After adjustment for illicit substance use, the strength of associations between gender and negative, manic and depression symptoms increased, whereas gender differences in aggression, agitation, paranoia and grandiosity became insignificant. Conclusions There are clear gender differences in the clinical presentation of FEP. Our findings suggest that gender can have a substantial influence on the nature of clinical presentation in people with psychosis, and that this is only partly explained by exposure to illicit substance use.",
keywords = "natural language processing, electronic case register, first episode psychosis, gender differences, substance abuse",
author = "Jessica Irving and Craig Colling and Hitesh Shetty and Megan Pritchard and Robert Stewart and Paolo Fusar-Poli and Philip McGuire and Rashmi Patel",
note = "Funding Information: Funding HS, MP, RS and PM receive funding from the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, which also supports the development and maintenance of the BRC Case Register. RP has received support from a Medical Research Council (MRC) Health Data Research UK Fellowship (MR/S003118/1) and a Starter Grant for Clinical Lecturers (SGL015/1020) supported by the Academy of Medical Sciences, The Wellcome Trust, MRC, British Heart Foundation, Arthritis Research UK, the Royal College of Physicians and Diabetes UK. Funding Information: Competing interests All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare: RS has received research funding from Roche, Janssen, GSK and Takeda. PFP has received grant funds from Lundbeck and honoraria from Lundbeck, Menarini and Angelini outside the current study. RP has received grant funds from Janssen and consultancy fees from Induction Healthcare and Holmusk. The other authors declare no competing interests. Publisher Copyright: {\textcopyright} 2021 Author(s) (or their employer(s). Re-use permitted under CC BY. Published by BMJ. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = apr,
day = "21",
doi = "10.1136/bmjopen-2020-042949",
language = "English",
volume = "11",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "4",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Gender differences in clinical presentation and illicit substance use during first episode psychosis: a natural language processing, electronic case register study

AU - Irving, Jessica

AU - Colling, Craig

AU - Shetty, Hitesh

AU - Pritchard, Megan

AU - Stewart, Robert

AU - Fusar-Poli, Paolo

AU - McGuire, Philip

AU - Patel, Rashmi

N1 - Funding Information: Funding HS, MP, RS and PM receive funding from the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, which also supports the development and maintenance of the BRC Case Register. RP has received support from a Medical Research Council (MRC) Health Data Research UK Fellowship (MR/S003118/1) and a Starter Grant for Clinical Lecturers (SGL015/1020) supported by the Academy of Medical Sciences, The Wellcome Trust, MRC, British Heart Foundation, Arthritis Research UK, the Royal College of Physicians and Diabetes UK. Funding Information: Competing interests All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare: RS has received research funding from Roche, Janssen, GSK and Takeda. PFP has received grant funds from Lundbeck and honoraria from Lundbeck, Menarini and Angelini outside the current study. RP has received grant funds from Janssen and consultancy fees from Induction Healthcare and Holmusk. The other authors declare no competing interests. Publisher Copyright: © 2021 Author(s) (or their employer(s). Re-use permitted under CC BY. Published by BMJ. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/4/21

Y1 - 2021/4/21

N2 - Objective To determine whether gender differences in symptom presentation at first episode psychosis (FEP) remain even when controlling for substance use, age and ethnicity, using natural language processing applied to electronic health records (EHRs). Design, setting and participants Data were extracted from EHRs of 3350 people (62% male patients) who had presented to the South London and Maudsley NHS Trust with a FEP between 1 April 2007 and 31 March 2017. Logistic regression was used to examine gender differences in the presentation of positive, negative, depressive, mania and disorganisation symptoms. Exposure(s) (for observational studies) Gender (male vs female). Main outcome(s) and measure(s) Presence of positive, negative, depressive, mania and disorganisation symptoms at initial clinical presentation. Results Eight symptoms were significantly more prevalent in men (poverty of thought, negative symptoms, social withdrawal, poverty of speech, aggression, grandiosity, paranoia and agitation). Conversely, tearfulness, low energy, reduced appetite, low mood, pressured speech, mood instability, flight of ideas, guilt, mutism, insomnia, poor concentration, tangentiality and elation were more prevalent in women than men. Negative symptoms were more common among men (OR 1.85, 95% CI 1.33 to 2.62) and depressive and manic symptoms more common among women (OR 0.30, 95% CI 0.26 to 0.35). After adjustment for illicit substance use, the strength of associations between gender and negative, manic and depression symptoms increased, whereas gender differences in aggression, agitation, paranoia and grandiosity became insignificant. Conclusions There are clear gender differences in the clinical presentation of FEP. Our findings suggest that gender can have a substantial influence on the nature of clinical presentation in people with psychosis, and that this is only partly explained by exposure to illicit substance use.

AB - Objective To determine whether gender differences in symptom presentation at first episode psychosis (FEP) remain even when controlling for substance use, age and ethnicity, using natural language processing applied to electronic health records (EHRs). Design, setting and participants Data were extracted from EHRs of 3350 people (62% male patients) who had presented to the South London and Maudsley NHS Trust with a FEP between 1 April 2007 and 31 March 2017. Logistic regression was used to examine gender differences in the presentation of positive, negative, depressive, mania and disorganisation symptoms. Exposure(s) (for observational studies) Gender (male vs female). Main outcome(s) and measure(s) Presence of positive, negative, depressive, mania and disorganisation symptoms at initial clinical presentation. Results Eight symptoms were significantly more prevalent in men (poverty of thought, negative symptoms, social withdrawal, poverty of speech, aggression, grandiosity, paranoia and agitation). Conversely, tearfulness, low energy, reduced appetite, low mood, pressured speech, mood instability, flight of ideas, guilt, mutism, insomnia, poor concentration, tangentiality and elation were more prevalent in women than men. Negative symptoms were more common among men (OR 1.85, 95% CI 1.33 to 2.62) and depressive and manic symptoms more common among women (OR 0.30, 95% CI 0.26 to 0.35). After adjustment for illicit substance use, the strength of associations between gender and negative, manic and depression symptoms increased, whereas gender differences in aggression, agitation, paranoia and grandiosity became insignificant. Conclusions There are clear gender differences in the clinical presentation of FEP. Our findings suggest that gender can have a substantial influence on the nature of clinical presentation in people with psychosis, and that this is only partly explained by exposure to illicit substance use.

KW - natural language processing

KW - electronic case register

KW - first episode psychosis

KW - gender differences

KW - substance abuse

UR - http://www.scopus.com/inward/record.url?scp=85104655501&partnerID=8YFLogxK

U2 - 10.1136/bmjopen-2020-042949

DO - 10.1136/bmjopen-2020-042949

M3 - Article

VL - 11

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 4

M1 - e042949

ER -

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