Gender-specific interactions between alcohol metabolism genes and severity of quantitative alcohol-related-traits in a Tibetan population

Wan-jun Guo, Qiang Wang, Gongga Lanzi, Ouzhu Luobu, Xiao-hong Ma, Ying-cheng Wang, Puo Zhen, Geng Wei, Wei Deng, Basang Zhuoma, Xiao-ming Shi, Xie-he Liu, Yue-jing Wu, Yan Xu, David A. Collier, David Ball, Xun Hu, Tao Li

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Association between genes influencing alcohol metabolism and alcohol use disorders (AUD) has been extensively studied, but the effect of interactions between these genes and AUD have rarely been tested. Our previous case-control study in a Tibetan population noted that the positive association between *c2 allele of cytochrome P4502E1 (CYP2E1) gene and AUD might only exist in males who are homozygotes for *1 alleles of aldehyde dehydrogenase-2 (ALDH2) and alcohol dehydrogenase-1B (ADH1B) genes, but this interaction did not reach statistical significance. Using the same set of data, the present study was aimed at exploring interactions between these genes and quantitative alcohol-related-trait scores (QARTs), and whether these are influenced by gender. The sample included 383 AUD cases with the alcohol use disorders identification test (AUDIT) score >= 10 and 350 normal controls with the AUDIT score
Original languageEnglish
Pages (from-to)22 - 25
Number of pages4
JournalNeuroscience Letters
Volume495
Issue number1
DOIs
Publication statusPublished - 9 May 2011

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