Gene-Environment Interaction in the Etiology of Mathematical Ability Using SNP Sets

TY - JOUR

T1 - Gene-Environment Interaction in the Etiology of Mathematical Ability Using SNP Sets

AU - Docherty, Sophia J.

AU - Kovas, Yulia

AU - Plomin, Robert

PY - 2011/1

Y1 - 2011/1

N2 - Mathematics ability and disability is as heritable as other cognitive abilities and disabilities, however its genetic etiology has received relatively little attention. In our recent genome-wide association study of mathematical ability in 10-year-old children, 10 SNP associations were nominated from scans of pooled DNA and validated in an individually genotyped sample. In this paper, we use a 'SNP set' composite of these 10 SNPs to investigate gene-environment (GE) interaction, examining whether the association between the 10-SNP set and mathematical ability differs as a function of ten environmental measures in the home and school in a sample of 1888 children with complete data. We found two significant GE interactions for environmental measures in the home and the school both in the direction of the diathesis-stress type of GE interaction: The 10-SNP set was more strongly associated with mathematical ability in chaotic homes and when parents are negative.

AB - Mathematics ability and disability is as heritable as other cognitive abilities and disabilities, however its genetic etiology has received relatively little attention. In our recent genome-wide association study of mathematical ability in 10-year-old children, 10 SNP associations were nominated from scans of pooled DNA and validated in an individually genotyped sample. In this paper, we use a 'SNP set' composite of these 10 SNPs to investigate gene-environment (GE) interaction, examining whether the association between the 10-SNP set and mathematical ability differs as a function of ten environmental measures in the home and school in a sample of 1888 children with complete data. We found two significant GE interactions for environmental measures in the home and the school both in the direction of the diathesis-stress type of GE interaction: The 10-SNP set was more strongly associated with mathematical ability in chaotic homes and when parents are negative.

KW - Mathematical ability

KW - Gene-environment interaction

KW - Cognitive traits

KW - SNP set

KW - Allelic association

U2 - 10.1007/s10519-010-9405-6

DO - 10.1007/s10519-010-9405-6

M3 - Article

SN - 1573-3297

VL - 41

SP - 141

EP - 154

JO - Behavior Genetics

JF - Behavior Genetics

IS - 1

ER -