Gene expression changes with age in skin, adipose tissue, blood and brain

Daniel Glass; Ana Vinuela; Matthew N. Davies; Adaikalavan Ramasamy; Leopold Parts; David Knowles; Andrew A. Brown; Asa K. Hedman; Kerrin S. Small; Alfonso Buil; Elin Grundberg; Alexandra C. Nica; Paola Di Meglio; Frank O. Nestle; Mina Ryten; Richard Durbin; Mark I. McCarthy; Panagiotis Deloukas; Emmanouil T. Dermitzakis; Michael E. Weale; Veronique Bataille; Tim D. Spector; UK Brain Expression Consortium; MuTHER Consortium

doi:10.1186/gb-2013-14-7-r75

Gene expression changes with age in skin, adipose tissue, blood and brain

Daniel Glass, Ana Vinuela, Matthew N. Davies, Adaikalavan Ramasamy, Leopold Parts, David Knowles, Andrew A. Brown, Asa K. Hedman, Kerrin S. Small, Alfonso Buil, Elin Grundberg, Alexandra C. Nica, Paola Di Meglio, Frank O. Nestle, Mina Ryten, Richard Durbin, Mark I. McCarthy, Panagiotis Deloukas, Emmanouil T. Dermitzakis, Michael E. WealeVeronique Bataille^*, Tim D. Spector, UK Brain Expression Consortium, MuTHER Consortium

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

216 Citations (Scopus)

Abstract

Background: Previous studies have demonstrated that gene expression levels change with age. These changes are hypothesized to influence the aging rate of an individual. We analyzed gene expression changes with age in abdominal skin, subcutaneous adipose tissue and lymphoblastoid cell lines in 856 female twins in the age range of 39-85 years. Additionally, we investigated genotypic variants involved in genotype-by-age interactions to understand how the genomic regulation of gene expression alters with age.

Results: Using a linear mixed model, differential expression with age was identified in 1,672 genes in skin and 188 genes in adipose tissue. Only two genes expressed in lymphoblastoid cell lines showed significant changes with age. Genes significantly regulated by age were compared with expression profiles in 10 brain regions from 100 postmortem brains aged 16 to 83 years. We identified only one age-related gene common to the three tissues. There were 12 genes that showed differential expression with age in both skin and brain tissue and three common to adipose and brain tissues.

Conclusions: Skin showed the most age-related gene expression changes of all the tissues investigated, with many of the genes being previously implicated in fatty acid metabolism, mitochondrial activity, cancer and splicing. A significant proportion of age-related changes in gene expression appear to be tissue-specific with only a few genes sharing an age effect in expression across tissues. More research is needed to improve our understanding of the genetic influences on aging and the relationship with age-related diseases.

Original language	English
Article number	R75
Pages (from-to)	N/A
Number of pages	12
Journal	GENOME BIOLOGY
Volume	14
Issue number	7
DOIs	https://doi.org/10.1186/gb-2013-14-7-r75
Publication status	Published - 26 Jul 2013

Keywords

Aging
gene expression
skin
adipose
brain
microarrays
PROSTATE-CANCER
CELL-SURVIVAL
C-ELEGANS
GENOTYPE
STRESS
P53
METAANALYSIS
MICROARRAYS
SENESCENCE
SIR2-ALPHA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/gb-2013-14-7-r75

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Glass, D., Vinuela, A., Davies, M. N., Ramasamy, A., Parts, L., Knowles, D., Brown, A. A., Hedman, A. K., Small, K. S., Buil, A., Grundberg, E., Nica, A. C., Di Meglio, P., Nestle, F. O., Ryten, M., Durbin, R., McCarthy, M. I., Deloukas, P., Dermitzakis, E. T., ... MuTHER Consortium (2013). Gene expression changes with age in skin, adipose tissue, blood and brain. GENOME BIOLOGY, 14(7), N/A. Article R75. https://doi.org/10.1186/gb-2013-14-7-r75

@article{0868ee1ed3d94082b26c5802175b316e,

title = "Gene expression changes with age in skin, adipose tissue, blood and brain",

abstract = "Background: Previous studies have demonstrated that gene expression levels change with age. These changes are hypothesized to influence the aging rate of an individual. We analyzed gene expression changes with age in abdominal skin, subcutaneous adipose tissue and lymphoblastoid cell lines in 856 female twins in the age range of 39-85 years. Additionally, we investigated genotypic variants involved in genotype-by-age interactions to understand how the genomic regulation of gene expression alters with age.Results: Using a linear mixed model, differential expression with age was identified in 1,672 genes in skin and 188 genes in adipose tissue. Only two genes expressed in lymphoblastoid cell lines showed significant changes with age. Genes significantly regulated by age were compared with expression profiles in 10 brain regions from 100 postmortem brains aged 16 to 83 years. We identified only one age-related gene common to the three tissues. There were 12 genes that showed differential expression with age in both skin and brain tissue and three common to adipose and brain tissues.Conclusions: Skin showed the most age-related gene expression changes of all the tissues investigated, with many of the genes being previously implicated in fatty acid metabolism, mitochondrial activity, cancer and splicing. A significant proportion of age-related changes in gene expression appear to be tissue-specific with only a few genes sharing an age effect in expression across tissues. More research is needed to improve our understanding of the genetic influences on aging and the relationship with age-related diseases.",

keywords = "Aging, gene expression, skin, adipose, brain, microarrays, PROSTATE-CANCER, CELL-SURVIVAL, C-ELEGANS, GENOTYPE, STRESS, P53, METAANALYSIS, MICROARRAYS, SENESCENCE, SIR2-ALPHA",

author = "Daniel Glass and Ana Vinuela and Davies, {Matthew N.} and Adaikalavan Ramasamy and Leopold Parts and David Knowles and Brown, {Andrew A.} and Hedman, {Asa K.} and Small, {Kerrin S.} and Alfonso Buil and Elin Grundberg and Nica, {Alexandra C.} and {Di Meglio}, Paola and Nestle, {Frank O.} and Mina Ryten and Richard Durbin and McCarthy, {Mark I.} and Panagiotis Deloukas and Dermitzakis, {Emmanouil T.} and Weale, {Michael E.} and Veronique Bataille and Spector, {Tim D.} and {UK Brain Expression Consortium} and {MuTHER Consortium}",

year = "2013",

month = jul,

day = "26",

doi = "10.1186/gb-2013-14-7-r75",

language = "English",

volume = "14",

pages = "N/A",

journal = "GENOME BIOLOGY",

issn = "1465-6906",

publisher = "BioMed Central",

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Glass, D, Vinuela, A, Davies, MN, Ramasamy, A, Parts, L, Knowles, D, Brown, AA, Hedman, AK, Small, KS, Buil, A, Grundberg, E, Nica, AC, Di Meglio, P , Nestle, FO, Ryten, M, Durbin, R, McCarthy, MI, Deloukas, P, Dermitzakis, ET, Weale, ME, Bataille, V, Spector, TD, UK Brain Expression Consortium & MuTHER Consortium 2013, 'Gene expression changes with age in skin, adipose tissue, blood and brain', GENOME BIOLOGY, vol. 14, no. 7, R75, pp. N/A. https://doi.org/10.1186/gb-2013-14-7-r75

TY - JOUR

T1 - Gene expression changes with age in skin, adipose tissue, blood and brain

AU - Glass, Daniel

AU - Vinuela, Ana

AU - Davies, Matthew N.

AU - Ramasamy, Adaikalavan

AU - Parts, Leopold

AU - Knowles, David

AU - Brown, Andrew A.

AU - Hedman, Asa K.

AU - Small, Kerrin S.

AU - Buil, Alfonso

AU - Grundberg, Elin

AU - Nica, Alexandra C.

AU - Di Meglio, Paola

AU - Nestle, Frank O.

AU - Ryten, Mina

AU - Durbin, Richard

AU - McCarthy, Mark I.

AU - Deloukas, Panagiotis

AU - Dermitzakis, Emmanouil T.

AU - Weale, Michael E.

AU - Bataille, Veronique

AU - Spector, Tim D.

AU - UK Brain Expression Consortium

AU - MuTHER Consortium

PY - 2013/7/26

Y1 - 2013/7/26

N2 - Background: Previous studies have demonstrated that gene expression levels change with age. These changes are hypothesized to influence the aging rate of an individual. We analyzed gene expression changes with age in abdominal skin, subcutaneous adipose tissue and lymphoblastoid cell lines in 856 female twins in the age range of 39-85 years. Additionally, we investigated genotypic variants involved in genotype-by-age interactions to understand how the genomic regulation of gene expression alters with age.Results: Using a linear mixed model, differential expression with age was identified in 1,672 genes in skin and 188 genes in adipose tissue. Only two genes expressed in lymphoblastoid cell lines showed significant changes with age. Genes significantly regulated by age were compared with expression profiles in 10 brain regions from 100 postmortem brains aged 16 to 83 years. We identified only one age-related gene common to the three tissues. There were 12 genes that showed differential expression with age in both skin and brain tissue and three common to adipose and brain tissues.Conclusions: Skin showed the most age-related gene expression changes of all the tissues investigated, with many of the genes being previously implicated in fatty acid metabolism, mitochondrial activity, cancer and splicing. A significant proportion of age-related changes in gene expression appear to be tissue-specific with only a few genes sharing an age effect in expression across tissues. More research is needed to improve our understanding of the genetic influences on aging and the relationship with age-related diseases.

AB - Background: Previous studies have demonstrated that gene expression levels change with age. These changes are hypothesized to influence the aging rate of an individual. We analyzed gene expression changes with age in abdominal skin, subcutaneous adipose tissue and lymphoblastoid cell lines in 856 female twins in the age range of 39-85 years. Additionally, we investigated genotypic variants involved in genotype-by-age interactions to understand how the genomic regulation of gene expression alters with age.Results: Using a linear mixed model, differential expression with age was identified in 1,672 genes in skin and 188 genes in adipose tissue. Only two genes expressed in lymphoblastoid cell lines showed significant changes with age. Genes significantly regulated by age were compared with expression profiles in 10 brain regions from 100 postmortem brains aged 16 to 83 years. We identified only one age-related gene common to the three tissues. There were 12 genes that showed differential expression with age in both skin and brain tissue and three common to adipose and brain tissues.Conclusions: Skin showed the most age-related gene expression changes of all the tissues investigated, with many of the genes being previously implicated in fatty acid metabolism, mitochondrial activity, cancer and splicing. A significant proportion of age-related changes in gene expression appear to be tissue-specific with only a few genes sharing an age effect in expression across tissues. More research is needed to improve our understanding of the genetic influences on aging and the relationship with age-related diseases.

KW - Aging

KW - gene expression

KW - skin

KW - adipose

KW - brain

KW - microarrays

KW - PROSTATE-CANCER

KW - CELL-SURVIVAL

KW - C-ELEGANS

KW - GENOTYPE

KW - STRESS

KW - P53

KW - METAANALYSIS

KW - MICROARRAYS

KW - SENESCENCE

KW - SIR2-ALPHA

U2 - 10.1186/gb-2013-14-7-r75

DO - 10.1186/gb-2013-14-7-r75

M3 - Article

SN - 1465-6906

VL - 14

SP - N/A

JO - GENOME BIOLOGY

JF - GENOME BIOLOGY

IS - 7

M1 - R75

ER -

Gene expression changes with age in skin, adipose tissue, blood and brain

Abstract

Keywords

UN SDGs

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