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Gene-Environment Interaction in the Etiology of Mathematical Ability Using SNP Sets

Research output: Contribution to journalArticle

Sophia J. Docherty, Yulia Kovas, Robert Plomin

Original languageEnglish
Pages (from-to)141 - 154
Number of pages14
JournalBehavior Genetics
Issue number1
Publication statusPublished - Jan 2011


King's Authors


Mathematics ability and disability is as heritable as other cognitive abilities and disabilities, however its genetic etiology has received relatively little attention. In our recent genome-wide association study of mathematical ability in 10-year-old children, 10 SNP associations were nominated from scans of pooled DNA and validated in an individually genotyped sample. In this paper, we use a 'SNP set' composite of these 10 SNPs to investigate gene-environment (GE) interaction, examining whether the association between the 10-SNP set and mathematical ability differs as a function of ten environmental measures in the home and school in a sample of 1888 children with complete data. We found two significant GE interactions for environmental measures in the home and the school both in the direction of the diathesis-stress type of GE interaction: The 10-SNP set was more strongly associated with mathematical ability in chaotic homes and when parents are negative.

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