Generalist genes and cognitive neuroscience

L M Butcher; J K J Kennedy; R Plomin

doi:10.1016/j.conb.2006.03.004

Generalist genes and cognitive neuroscience

L M Butcher, J K J Kennedy, R Plomin

Social Genetic & Developmental Psychiatry

Research output: Contribution to journal › Literature review › peer-review

32 Citations (Scopus)

Abstract

Multivariate genetic research suggests that a single set of genes affects most cognitive abilities and disabilities. This finding already has far-reaching implications for cognitive neuroscience, and will become even more revealing when this - presumably large - set of generalist genes is identified. Similar to other complex disorders and dimensions, molecular genetic research on cognitive abilities and disabilities is adopting genome-wide association strategies. These strategies involve very large samples to detect DNA associations of small effect size using microarrays that simultaneously assess hundreds of thousands of DNA markers. When this set of generalist genes is identified, it can be used to provide solid footholds in the climb towards a systems-level understanding of how genetically driven brain processes work together to affect diverse cognitive abilities and disabilities

Original language	English
Pages (from-to)	145 - 151
Number of pages	7
Journal	CURRENT OPINION IN NEUROBIOLOGY
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/j.conb.2006.03.004
Publication status	Published - Apr 2006

Access to Document

10.1016/j.conb.2006.03.004

Origins of learning difficulties and behaviour problems: From behavioural genetics to behavioural genomics
Plomin, R.
MRC Medical Research Council
1/10/2005 → 30/09/2010
Project: Research

Cite this

@article{66a6cbcf38b544468186070122d13618,

title = "Generalist genes and cognitive neuroscience",

abstract = "Multivariate genetic research suggests that a single set of genes affects most cognitive abilities and disabilities. This finding already has far-reaching implications for cognitive neuroscience, and will become even more revealing when this - presumably large - set of generalist genes is identified. Similar to other complex disorders and dimensions, molecular genetic research on cognitive abilities and disabilities is adopting genome-wide association strategies. These strategies involve very large samples to detect DNA associations of small effect size using microarrays that simultaneously assess hundreds of thousands of DNA markers. When this set of generalist genes is identified, it can be used to provide solid footholds in the climb towards a systems-level understanding of how genetically driven brain processes work together to affect diverse cognitive abilities and disabilities",

author = "Butcher, {L M} and Kennedy, {J K J} and R Plomin",

year = "2006",

month = apr,

doi = "10.1016/j.conb.2006.03.004",

language = "English",

volume = "16",

pages = "145 -- 151",

journal = "CURRENT OPINION IN NEUROBIOLOGY",

issn = "1873-6882",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Generalist genes and cognitive neuroscience

AU - Butcher, L M

AU - Kennedy, J K J

AU - Plomin, R

PY - 2006/4

Y1 - 2006/4

N2 - Multivariate genetic research suggests that a single set of genes affects most cognitive abilities and disabilities. This finding already has far-reaching implications for cognitive neuroscience, and will become even more revealing when this - presumably large - set of generalist genes is identified. Similar to other complex disorders and dimensions, molecular genetic research on cognitive abilities and disabilities is adopting genome-wide association strategies. These strategies involve very large samples to detect DNA associations of small effect size using microarrays that simultaneously assess hundreds of thousands of DNA markers. When this set of generalist genes is identified, it can be used to provide solid footholds in the climb towards a systems-level understanding of how genetically driven brain processes work together to affect diverse cognitive abilities and disabilities

AB - Multivariate genetic research suggests that a single set of genes affects most cognitive abilities and disabilities. This finding already has far-reaching implications for cognitive neuroscience, and will become even more revealing when this - presumably large - set of generalist genes is identified. Similar to other complex disorders and dimensions, molecular genetic research on cognitive abilities and disabilities is adopting genome-wide association strategies. These strategies involve very large samples to detect DNA associations of small effect size using microarrays that simultaneously assess hundreds of thousands of DNA markers. When this set of generalist genes is identified, it can be used to provide solid footholds in the climb towards a systems-level understanding of how genetically driven brain processes work together to affect diverse cognitive abilities and disabilities

U2 - 10.1016/j.conb.2006.03.004

DO - 10.1016/j.conb.2006.03.004

M3 - Literature review

SN - 1873-6882

VL - 16

SP - 145

EP - 151

JO - CURRENT OPINION IN NEUROBIOLOGY

JF - CURRENT OPINION IN NEUROBIOLOGY

IS - 2

ER -

Generalist genes and cognitive neuroscience

Abstract

Access to Document

Fingerprint

Projects

Origins of learning difficulties and behaviour problems: From behavioural genetics to behavioural genomics

Cite this