Generation of CD8(+) T cell-generated suppressor factor and beta-chemokines by targeted iliac lymph node immunization in rhesus monkeys challenged with SHIV-89.6P by the rectal route

A M Aubertin; R Le Grand; Y F Wang; C Beyer; L Tao; O Neildez; F Barre-Sinoussi; B Hurtrel; C Moog; T Lehner; M Girard

doi:10.1089/088922200309269

Generation of CD8(+) T cell-generated suppressor factor and beta-chemokines by targeted iliac lymph node immunization in rhesus monkeys challenged with SHIV-89.6P by the rectal route

A M Aubertin, R Le Grand, Y F Wang, C Beyer, L Tao, O Neildez, F Barre-Sinoussi, B Hurtrel, C Moog, T Lehner, M Girard

Centre for Host Microbiome Interactions

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The targeted lymph node (TLN) immunization strategy was investigated in macaques, in order to determine the efficacy in generating secretory, systemic, and cellular immune responses, CD8(+) T cell-generated suppressor factors, and beta-chemokines, TLN immunization of the rectal and genital mucosa-associated iliac lymph nodes (TILNs) was compared with axillary TLN immunization (TAxLN) using HIV-1 MN/LAI gp140(env) and SIV p27(gag) in alum. Significantly higher immune responses, as well as CD8(+) T cell-generated anti-SIV factors and the beta-chemokines RANTES, MIP-1 alpha, and MIP-1 beta, were elicited by iliac as compared with axillary TLN immunization. The immune responses induced by TLN immunization were examined for their capacity to prevent rectal mucosal infection by the pathogenic dual-tropic SHIV-89.6P, Despite significant secretory, serum, cellular, and beta-chemokine responses, the macaques were infected by SHIV-89.6P. Whether the lack of protection was associated with the antigenic unrelatedness of SHIV-89.6P to the immunizing HIV-1 MN/LAI gp140 or to the virus utilizing CXCR4 to a much greater extent than CCR5, remains to be determined.

Original language	English
Pages (from-to)	381 - 392
Number of pages	12
Journal	Aids Research and Human Retroviruses
Volume	16
Issue number	4
DOIs	https://doi.org/10.1089/088922200309269
Publication status	Published - 2000

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Aubertin, A. M., Le Grand, R., Wang, Y. F., Beyer, C., Tao, L., Neildez, O., Barre-Sinoussi, F., Hurtrel, B., Moog, C., Lehner, T., & Girard, M. (2000). Generation of CD8(+) T cell-generated suppressor factor and beta-chemokines by targeted iliac lymph node immunization in rhesus monkeys challenged with SHIV-89.6P by the rectal route. Aids Research and Human Retroviruses, 16(4), 381 - 392. https://doi.org/10.1089/088922200309269

@article{bcdb6fe123184e5bae43186c69af1e4b,

title = "Generation of CD8(+) T cell-generated suppressor factor and beta-chemokines by targeted iliac lymph node immunization in rhesus monkeys challenged with SHIV-89.6P by the rectal route",

abstract = "The targeted lymph node (TLN) immunization strategy was investigated in macaques, in order to determine the efficacy in generating secretory, systemic, and cellular immune responses, CD8(+) T cell-generated suppressor factors, and beta-chemokines, TLN immunization of the rectal and genital mucosa-associated iliac lymph nodes (TILNs) was compared with axillary TLN immunization (TAxLN) using HIV-1 MN/LAI gp140(env) and SIV p27(gag) in alum. Significantly higher immune responses, as well as CD8(+) T cell-generated anti-SIV factors and the beta-chemokines RANTES, MIP-1 alpha, and MIP-1 beta, were elicited by iliac as compared with axillary TLN immunization. The immune responses induced by TLN immunization were examined for their capacity to prevent rectal mucosal infection by the pathogenic dual-tropic SHIV-89.6P, Despite significant secretory, serum, cellular, and beta-chemokine responses, the macaques were infected by SHIV-89.6P. Whether the lack of protection was associated with the antigenic unrelatedness of SHIV-89.6P to the immunizing HIV-1 MN/LAI gp140 or to the virus utilizing CXCR4 to a much greater extent than CCR5, remains to be determined.",

author = "Aubertin, {A M} and {Le Grand}, R and Wang, {Y F} and C Beyer and L Tao and O Neildez and F Barre-Sinoussi and B Hurtrel and C Moog and T Lehner and M Girard",

year = "2000",

doi = "10.1089/088922200309269",

language = "English",

volume = "16",

pages = "381 -- 392",

journal = "Aids Research and Human Retroviruses",

publisher = "Mary Ann Liebert Inc.",

number = "4",

}

Aubertin, AM, Le Grand, R, Wang, YF, Beyer, C, Tao, L, Neildez, O, Barre-Sinoussi, F, Hurtrel, B, Moog, C, Lehner, T & Girard, M 2000, 'Generation of CD8(+) T cell-generated suppressor factor and beta-chemokines by targeted iliac lymph node immunization in rhesus monkeys challenged with SHIV-89.6P by the rectal route', Aids Research and Human Retroviruses, vol. 16, no. 4, pp. 381 - 392. https://doi.org/10.1089/088922200309269

Generation of CD8(+) T cell-generated suppressor factor and beta-chemokines by targeted iliac lymph node immunization in rhesus monkeys challenged with SHIV-89.6P by the rectal route. / Aubertin, A M; Le Grand, R; Wang, Y F et al.
In: Aids Research and Human Retroviruses, Vol. 16, No. 4, 2000, p. 381 - 392.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Generation of CD8(+) T cell-generated suppressor factor and beta-chemokines by targeted iliac lymph node immunization in rhesus monkeys challenged with SHIV-89.6P by the rectal route

AU - Aubertin, A M

AU - Le Grand, R

AU - Wang, Y F

AU - Beyer, C

AU - Tao, L

AU - Neildez, O

AU - Barre-Sinoussi, F

AU - Hurtrel, B

AU - Moog, C

AU - Lehner, T

AU - Girard, M

PY - 2000

Y1 - 2000

N2 - The targeted lymph node (TLN) immunization strategy was investigated in macaques, in order to determine the efficacy in generating secretory, systemic, and cellular immune responses, CD8(+) T cell-generated suppressor factors, and beta-chemokines, TLN immunization of the rectal and genital mucosa-associated iliac lymph nodes (TILNs) was compared with axillary TLN immunization (TAxLN) using HIV-1 MN/LAI gp140(env) and SIV p27(gag) in alum. Significantly higher immune responses, as well as CD8(+) T cell-generated anti-SIV factors and the beta-chemokines RANTES, MIP-1 alpha, and MIP-1 beta, were elicited by iliac as compared with axillary TLN immunization. The immune responses induced by TLN immunization were examined for their capacity to prevent rectal mucosal infection by the pathogenic dual-tropic SHIV-89.6P, Despite significant secretory, serum, cellular, and beta-chemokine responses, the macaques were infected by SHIV-89.6P. Whether the lack of protection was associated with the antigenic unrelatedness of SHIV-89.6P to the immunizing HIV-1 MN/LAI gp140 or to the virus utilizing CXCR4 to a much greater extent than CCR5, remains to be determined.

AB - The targeted lymph node (TLN) immunization strategy was investigated in macaques, in order to determine the efficacy in generating secretory, systemic, and cellular immune responses, CD8(+) T cell-generated suppressor factors, and beta-chemokines, TLN immunization of the rectal and genital mucosa-associated iliac lymph nodes (TILNs) was compared with axillary TLN immunization (TAxLN) using HIV-1 MN/LAI gp140(env) and SIV p27(gag) in alum. Significantly higher immune responses, as well as CD8(+) T cell-generated anti-SIV factors and the beta-chemokines RANTES, MIP-1 alpha, and MIP-1 beta, were elicited by iliac as compared with axillary TLN immunization. The immune responses induced by TLN immunization were examined for their capacity to prevent rectal mucosal infection by the pathogenic dual-tropic SHIV-89.6P, Despite significant secretory, serum, cellular, and beta-chemokine responses, the macaques were infected by SHIV-89.6P. Whether the lack of protection was associated with the antigenic unrelatedness of SHIV-89.6P to the immunizing HIV-1 MN/LAI gp140 or to the virus utilizing CXCR4 to a much greater extent than CCR5, remains to be determined.

UR - http://www.scopus.com/inward/record.url?scp=0034090607&partnerID=8YFLogxK

U2 - 10.1089/088922200309269

DO - 10.1089/088922200309269

M3 - Article

VL - 16

SP - 381

EP - 392

JO - Aids Research and Human Retroviruses

JF - Aids Research and Human Retroviruses

IS - 4

ER -

Generation of CD8(+) T cell-generated suppressor factor and beta-chemokines by targeted iliac lymph node immunization in rhesus monkeys challenged with SHIV-89.6P by the rectal route

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