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Generation of Immunoglobulin diversity in human gut-associated lymphoid tissue

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)139 - 146
Number of pages8
JournalSeminars in Immunology
Volume21
Issue number3
DOIs
PublishedJun 2009

King's Authors

Abstract

The organised gut associated lymphoid tissue (GALT) exists adjacent to an extensive and diverse luminal flora. The follicle associated epithelium and associated dendritic cells and lymphocytes form a tightly fortified gateway between the flora and the host that permits connectivity between them and chronic activation of the lymphoid compartment. As a consequence, plasma cell precursors are generated continuously, and in abundance, in GALT by clonal proliferation. Clonal proliferation alone on this scale would reduce the spectrum of B cell specificity. To compensate, GALT also houses molecular machinery that diversifies the receptor repertoire by somatic hypermutation, class switch recombination and receptor revision. These three processes of enhancing the diversity of mature B cells ensure that although clonally related plasma cells may secrete immunoglobulin side by side in the mucosa they rarely have identical antigen binding sites.

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