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Generation of KCL026 research grade human embryonic stem cell line carrying a mutation in SMN1 gene

Research output: Contribution to journalArticle

Heema Hewitson, Victoria Wood, Neli Kadeva, Glenda Cornwell, Stefano Codognotto, Emma Stephenson, Dusko Ilic

Original languageEnglish
Pages (from-to)249-251
Number of pages3
JournalStem Cell Research
Issue number2
Early online date14 Jan 2016
Accepted/In press12 Jan 2016
E-pub ahead of print14 Jan 2016
PublishedMar 2016


King's Authors


The KCL026 human embryonic stem cell line was derived from an embryo donated for research that carried a mutation in the SMN1 gene encoding survival of motor neuron 1, telomeric (exons 7 and 8 deletion). Mutations in this gene are associated with spinal muscular atrophy. The ICM was isolated using laser microsurgery and plated on γ-irradiated human foreskin fibroblasts. Both the derivation and cell line propagation were performed in an animal product-free environment. Pluripotent state and differentiation potential were confirmed by in vitro assays.

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