Generic brain activation mapping in fMRI: a non-parametric approach

Michael Brammer; E T Bullmore; Andrew Simmons; Steven Williams; P Grasby; R Howard; P W Woodruff; S Rabe-Hesketh

doi:10.1016/S0730-725X(97)00135-5

Generic brain activation mapping in fMRI: a non-parametric approach

Michael Brammer, E T Bullmore, Andrew Simmons, Steven Williams, P Grasby, R Howard, P W Woodruff, S Rabe-Hesketh

Neuroimaging

Research output: Contribution to journal › Article › peer-review

448 Citations (Scopus)

Abstract

We report a novel method to identify brain regions generically activated by periodic experimental design in functional magnetic resonance imaging data. This involves: 1) registering each of N individual functional magnetic resonance imaging datasets in a standard space; 2) computing the median standardised power of response to the experimental design; 3) testing median standardised power at each voxel against its nonparametrically ascertained distribution under the null hypothesis of no experimental effect; and 4) constructing a generic brain activation map. The method is validated by analysis of 6 null images, acquired under conditions when the null hypothesis was known to be true; 8 images acquired during periodic auditory-verbal stimulation; and 6 images acquired during periodic performance of a covert verbal fluency task.

Original language	English
Pages (from-to)	763-770
Journal	Magnetic Resonance Imaging
Volume	15
Issue number	7
DOIs	https://doi.org/10.1016/S0730-725X(97)00135-5
Publication status	Published - 1997

Access to Document

10.1016/S0730-725X(97)00135-5

Cite this

@article{cad9c85543d24032b79b802897e59bef,

title = "Generic brain activation mapping in fMRI: a non-parametric approach",

abstract = "We report a novel method to identify brain regions generically activated by periodic experimental design in functional magnetic resonance imaging data. This involves: 1) registering each of N individual functional magnetic resonance imaging datasets in a standard space; 2) computing the median standardised power of response to the experimental design; 3) testing median standardised power at each voxel against its nonparametrically ascertained distribution under the null hypothesis of no experimental effect; and 4) constructing a generic brain activation map. The method is validated by analysis of 6 null images, acquired under conditions when the null hypothesis was known to be true; 8 images acquired during periodic auditory-verbal stimulation; and 6 images acquired during periodic performance of a covert verbal fluency task.",

author = "Michael Brammer and Bullmore, {E T} and Andrew Simmons and Steven Williams and P Grasby and R Howard and Woodruff, {P W} and S Rabe-Hesketh",

year = "1997",

doi = "10.1016/S0730-725X(97)00135-5",

language = "English",

volume = "15",

pages = "763--770",

journal = "Magnetic Resonance Imaging",

issn = "0730-725X",

publisher = "Elsevier",

number = "7",

}

TY - JOUR

T1 - Generic brain activation mapping in fMRI

T2 - a non-parametric approach

AU - Brammer, Michael

AU - Bullmore, E T

AU - Simmons, Andrew

AU - Williams, Steven

AU - Grasby, P

AU - Howard, R

AU - Woodruff, P W

AU - Rabe-Hesketh, S

PY - 1997

Y1 - 1997

N2 - We report a novel method to identify brain regions generically activated by periodic experimental design in functional magnetic resonance imaging data. This involves: 1) registering each of N individual functional magnetic resonance imaging datasets in a standard space; 2) computing the median standardised power of response to the experimental design; 3) testing median standardised power at each voxel against its nonparametrically ascertained distribution under the null hypothesis of no experimental effect; and 4) constructing a generic brain activation map. The method is validated by analysis of 6 null images, acquired under conditions when the null hypothesis was known to be true; 8 images acquired during periodic auditory-verbal stimulation; and 6 images acquired during periodic performance of a covert verbal fluency task.

AB - We report a novel method to identify brain regions generically activated by periodic experimental design in functional magnetic resonance imaging data. This involves: 1) registering each of N individual functional magnetic resonance imaging datasets in a standard space; 2) computing the median standardised power of response to the experimental design; 3) testing median standardised power at each voxel against its nonparametrically ascertained distribution under the null hypothesis of no experimental effect; and 4) constructing a generic brain activation map. The method is validated by analysis of 6 null images, acquired under conditions when the null hypothesis was known to be true; 8 images acquired during periodic auditory-verbal stimulation; and 6 images acquired during periodic performance of a covert verbal fluency task.

U2 - 10.1016/S0730-725X(97)00135-5

DO - 10.1016/S0730-725X(97)00135-5

M3 - Article

SN - 0730-725X

VL - 15

SP - 763

EP - 770

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

IS - 7

ER -

Generic brain activation mapping in fMRI: a non-parametric approach

Abstract

Access to Document

Fingerprint

Cite this