Generic ICD programming and outcomes

Parisha Khan*, Nishat Jahagirdar, Micaela Laybourn, Idris Harding, Antonio Cannatà, Daniel I. Bromage, Husain Shabeeh, Peter Kabunga, Edward Petzer, Francis Murgatroyd, Paul A. Scott

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Introduction: Generic ICD programming, where shock-reduction programming is extrapolated from trials of one manufacturer to another, may reduce non-essential ICD therapies beyond that seen in randomized trials. However, the benefits and risks are unknown. The purpose of this retrospective cohort study was to evaluate the impact of a standardized programming protocol, based on generic programming, across manufacturers. Methods: We included all new ICDs in a single center (2009–2019). In 2013 a standardized programming protocol based on generic programming was introduced, incorporating high detection rates (200 bpm for primary prevention) and long detection (30/40 or equivalent in VF zone) for all patients. Patients were classified into three groups based on implant programming: pre-guideline (PS), post-guideline and guideline compliant (GC) and post-guideline but not guideline compliant (NGC). The end-points were the first occurrence of any device therapy (ATP or shock), ICD shock, syncope and all-cause mortality. Survival analysis was used to evaluate outcomes. Results: 1003 patients were included (mean follow-up 1519 ± 1005 days). In primary prevention patients (n = 583) freedom from ICD therapy (91.5% vs. 73.6%, p <.001) or shock (94.7% vs 84.8%, p =.02) were significantly higher in GC compared to PS patients, without significant increase in syncope or mortality. In secondary prevention patients (n = 420) freedom from any ICD therapy or any shock were non-significantly higher in GC compared to PS patients, without an increase in syncope or mortality. Conclusions: In primary prevention patients a standardized programming protocol, incorporating generic programming, reduced the burden of ICD therapy without an increase in adverse outcomes.

Original languageEnglish
Pages (from-to)1995-2004
Number of pages10
JournalPACE - Pacing and Clinical Electrophysiology
Issue number12
Early online date2 Nov 2021
Publication statusPublished - Dec 2021


  • antitachycardia pacing
  • implantable cardioverter-defibrillator
  • programming
  • shocks tachycardiac detection
  • ventricular tachycardia


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