Genes, molecules and patients - Emerging topics to guide clinical pain research

Shafaq Sikandar*, Ryan Patel, Sital Patel, Sanam Sikander, David L.H. Bennett, Anthony H. Dickenson

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

This review selectively explores some areas of pain research that, until recently, have been poorly understood. We have chosen four topics that relate to clinical pain and we discuss the underlying mechanisms and related pathophysiologies contributing to these pain states. A key issue in pain medicine involves crucial events and mediators that contribute to normal and abnormal pain signaling, but remain unseen without genetic, biomarker or imaging analysis. Here we consider how the altered genetic make-up of familial pains reveals the human importance of channels discovered by preclinical research, followed by the contribution of receptors as stimulus transducers in cold sensing and cold pain. Finally we review recent data on the neuro-immune interactions in chronic pain and the potential targets for treatment in cancer-induced bone pain.

Original languageEnglish
Pages (from-to)188-202
Number of pages15
JournalEuropean Journal of Pharmacology
Volume716
Issue number1-3
DOIs
Publication statusPublished - 15 Sept 2013

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