Genes, molecules and patients - Emerging topics to guide clinical pain research

Shafaq Sikandar; Ryan Patel; Sital Patel; Sanam Sikander; David L.H. Bennett; Anthony H. Dickenson

doi:10.1016/j.ejphar.2013.01.069

Genes, molecules and patients - Emerging topics to guide clinical pain research

Shafaq Sikandar^*, Ryan Patel, Sital Patel, Sanam Sikander, David L.H. Bennett, Anthony H. Dickenson

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

Abstract

This review selectively explores some areas of pain research that, until recently, have been poorly understood. We have chosen four topics that relate to clinical pain and we discuss the underlying mechanisms and related pathophysiologies contributing to these pain states. A key issue in pain medicine involves crucial events and mediators that contribute to normal and abnormal pain signaling, but remain unseen without genetic, biomarker or imaging analysis. Here we consider how the altered genetic make-up of familial pains reveals the human importance of channels discovered by preclinical research, followed by the contribution of receptors as stimulus transducers in cold sensing and cold pain. Finally we review recent data on the neuro-immune interactions in chronic pain and the potential targets for treatment in cancer-induced bone pain.

Original language	English
Pages (from-to)	188-202
Number of pages	15
Journal	European Journal of Pharmacology
Volume	716
Issue number	1-3
DOIs	https://doi.org/10.1016/j.ejphar.2013.01.069
Publication status	Published - 15 Sept 2013

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10.1016/j.ejphar.2013.01.069

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title = "Genes, molecules and patients - Emerging topics to guide clinical pain research",

abstract = "This review selectively explores some areas of pain research that, until recently, have been poorly understood. We have chosen four topics that relate to clinical pain and we discuss the underlying mechanisms and related pathophysiologies contributing to these pain states. A key issue in pain medicine involves crucial events and mediators that contribute to normal and abnormal pain signaling, but remain unseen without genetic, biomarker or imaging analysis. Here we consider how the altered genetic make-up of familial pains reveals the human importance of channels discovered by preclinical research, followed by the contribution of receptors as stimulus transducers in cold sensing and cold pain. Finally we review recent data on the neuro-immune interactions in chronic pain and the potential targets for treatment in cancer-induced bone pain.",

author = "Shafaq Sikandar and Ryan Patel and Sital Patel and Sanam Sikander and Bennett, {David L.H.} and Dickenson, {Anthony H.}",

note = "Funding Information: This work was supported by IMI Europain (Shafaq S.) , BBSRC (Sital P.) , BBSRC-CASE with Takeda Cambridge Ltd (Ryan P.) and the London Pain Consortium (Sanam S., AHD, DLHB) . The authors would also like to thank lovely Dr. Richard Michael Gordon-Williams for contriving Fig. 4 . Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2013",

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doi = "10.1016/j.ejphar.2013.01.069",

language = "English",

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T1 - Genes, molecules and patients - Emerging topics to guide clinical pain research

AU - Sikandar, Shafaq

AU - Patel, Ryan

AU - Patel, Sital

AU - Sikander, Sanam

AU - Bennett, David L.H.

AU - Dickenson, Anthony H.

N1 - Funding Information: This work was supported by IMI Europain (Shafaq S.) , BBSRC (Sital P.) , BBSRC-CASE with Takeda Cambridge Ltd (Ryan P.) and the London Pain Consortium (Sanam S., AHD, DLHB) . The authors would also like to thank lovely Dr. Richard Michael Gordon-Williams for contriving Fig. 4 . Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2013/9/15

Y1 - 2013/9/15

N2 - This review selectively explores some areas of pain research that, until recently, have been poorly understood. We have chosen four topics that relate to clinical pain and we discuss the underlying mechanisms and related pathophysiologies contributing to these pain states. A key issue in pain medicine involves crucial events and mediators that contribute to normal and abnormal pain signaling, but remain unseen without genetic, biomarker or imaging analysis. Here we consider how the altered genetic make-up of familial pains reveals the human importance of channels discovered by preclinical research, followed by the contribution of receptors as stimulus transducers in cold sensing and cold pain. Finally we review recent data on the neuro-immune interactions in chronic pain and the potential targets for treatment in cancer-induced bone pain.

AB - This review selectively explores some areas of pain research that, until recently, have been poorly understood. We have chosen four topics that relate to clinical pain and we discuss the underlying mechanisms and related pathophysiologies contributing to these pain states. A key issue in pain medicine involves crucial events and mediators that contribute to normal and abnormal pain signaling, but remain unseen without genetic, biomarker or imaging analysis. Here we consider how the altered genetic make-up of familial pains reveals the human importance of channels discovered by preclinical research, followed by the contribution of receptors as stimulus transducers in cold sensing and cold pain. Finally we review recent data on the neuro-immune interactions in chronic pain and the potential targets for treatment in cancer-induced bone pain.

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DO - 10.1016/j.ejphar.2013.01.069

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AN - SCOPUS:84892513930

SN - 0014-2999

VL - 716

SP - 188

EP - 202

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1-3

ER -

Genes, molecules and patients - Emerging topics to guide clinical pain research

Abstract

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