Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

TY - JOUR

T1 - Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

AU - Million Veteran Program

AU - Evangelou, Evangelos

AU - Warren, Helen R

AU - Mosen-Ansorena, David

AU - Mifsud, Borbala

AU - Pazoki, Raha

AU - Gao, He

AU - Ntritsos, Georgios

AU - Dimou, Niki

AU - Cabrera, Claudia P

AU - Karaman, Ibrahim

AU - Ng, Fu Liang

AU - Evangelou, Marina

AU - Witkowska, Katarzyna

AU - Tzanis, Evan

AU - Hellwege, Jacklyn N

AU - Giri, Ayush

AU - Velez Edwards, Digna R

AU - Sun, Yan V

AU - Cho, Kelly

AU - Gaziano, J Michael

AU - Wilson, Peter W F

AU - Tsao, Philip S

AU - Kovesdy, Csaba P

AU - Esko, Tonu

AU - Mägi, Reedik

AU - Milani, Lili

AU - Almgren, Peter

AU - Boutin, Thibaud

AU - Debette, Stéphanie

AU - Ding, Jun

AU - Giulianini, Franco

AU - Holliday, Elizabeth G

AU - Jackson, Anne U

AU - Li-Gao, Ruifang

AU - Lin, Wei-Yu

AU - Luan, Jian'an

AU - Mangino, Massimo

AU - Oldmeadow, Christopher

AU - Prins, Bram Peter

AU - Qian, Yong

AU - Sargurupremraj, Muralidharan

AU - Shah, Nabi

AU - Surendran, Praveen

AU - Thériault, Sébastien

AU - Verweij, Niek

AU - Willems, Sara M

AU - Zhao, Jing-Hua

AU - Menni, Cristina

AU - O'Reilly, Paul F

AU - Spector, Tim D

PY - 2018/9/17

Y1 - 2018/9/17

N2 - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

AB - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

U2 - 10.1038/s41588-018-0205-x

DO - 10.1038/s41588-018-0205-x

M3 - Article

C2 - 30224653

SN - 1061-4036

VL - 50

SP - 1412

EP - 1425

JO - Nature Genetics

JF - Nature Genetics

IS - 10

ER -