Abstract
Aim
This study aimed to investigate the factors associated with periodontal traits considering genetic and environmental background in predominantly older female twins.
Methods
This was a cross‐sectional study using self‐reported questionnaires for periodontal traits in TwinsUK. Age‐adjusted and age‐stratified multivariate analyses were conducted for all twins. Subsequently, co‐twin control analysis within genetically‐identical twins who were discordant for periodontal traits was performed by controlling for genetic confounders.
Results
Data of twins aged 20‐91 were available in 4143 individuals for self‐reported periodontitis and 4244 for gum bleeding. Age‐adjusted model showed increasing risk in: smoking, anxiety/stress and depression for both periodontal traits. Within discordant monozygotic twins (514 individuals for periodontitis and 754 for gum bleeding), the association of anxiety/stress remained significant both for periodontitis (OR 1.60, CI 1.02‐2.52) and gum bleeding (OR 1.60, CI 1.06‐2.40). A significant relationship for depression remained for periodontitis (OR 1.68, CI 1.04‐2.70), but it was no longer significant for gum bleeding. Age‐stratification showed that the association of mood disorders with periodontal traits was generally stronger in older group.
Conclusions
Multivariate analysis among discordant monozygotic female twins found mood disorders were independently associated with periodontal traits, suggesting that genetic / early life environmental factors may not explain this association.
This article is protected by copyright. All rights reserved.
This study aimed to investigate the factors associated with periodontal traits considering genetic and environmental background in predominantly older female twins.
Methods
This was a cross‐sectional study using self‐reported questionnaires for periodontal traits in TwinsUK. Age‐adjusted and age‐stratified multivariate analyses were conducted for all twins. Subsequently, co‐twin control analysis within genetically‐identical twins who were discordant for periodontal traits was performed by controlling for genetic confounders.
Results
Data of twins aged 20‐91 were available in 4143 individuals for self‐reported periodontitis and 4244 for gum bleeding. Age‐adjusted model showed increasing risk in: smoking, anxiety/stress and depression for both periodontal traits. Within discordant monozygotic twins (514 individuals for periodontitis and 754 for gum bleeding), the association of anxiety/stress remained significant both for periodontitis (OR 1.60, CI 1.02‐2.52) and gum bleeding (OR 1.60, CI 1.06‐2.40). A significant relationship for depression remained for periodontitis (OR 1.68, CI 1.04‐2.70), but it was no longer significant for gum bleeding. Age‐stratification showed that the association of mood disorders with periodontal traits was generally stronger in older group.
Conclusions
Multivariate analysis among discordant monozygotic female twins found mood disorders were independently associated with periodontal traits, suggesting that genetic / early life environmental factors may not explain this association.
This article is protected by copyright. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 40-50 |
| Number of pages | 11 |
| Journal | Journal of Clinical Periodontology |
| Volume | 46 |
| Issue number | 1 |
| Early online date | 8 Dec 2018 |
| DOIs | |
| Publication status | Published - 21 Jan 2019 |
Keywords
- cross-sectional study
- mental health
- periodontal disease
- population-based study
- twin study