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Genetic and environmental contributions to the association between mood disorder and periodontal disease: A cross-sectional study among female twins in the UK

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Original languageEnglish
Pages (from-to)40-50
Number of pages11
JournalJournal of Clinical Periodontology
Volume46
Issue number1
Early online date8 Dec 2018
DOIs
Accepted/In press3 Dec 2018
E-pub ahead of print8 Dec 2018
Published21 Jan 2019

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Abstract

Aim
This study aimed to investigate the factors associated with periodontal traits considering genetic and environmental background in predominantly older female twins.
Methods
This was a cross‐sectional study using self‐reported questionnaires for periodontal traits in TwinsUK. Age‐adjusted and age‐stratified multivariate analyses were conducted for all twins. Subsequently, co‐twin control analysis within genetically‐identical twins who were discordant for periodontal traits was performed by controlling for genetic confounders.
Results
Data of twins aged 20‐91 were available in 4143 individuals for self‐reported periodontitis and 4244 for gum bleeding. Age‐adjusted model showed increasing risk in: smoking, anxiety/stress and depression for both periodontal traits. Within discordant monozygotic twins (514 individuals for periodontitis and 754 for gum bleeding), the association of anxiety/stress remained significant both for periodontitis (OR 1.60, CI 1.02‐2.52) and gum bleeding (OR 1.60, CI 1.06‐2.40). A significant relationship for depression remained for periodontitis (OR 1.68, CI 1.04‐2.70), but it was no longer significant for gum bleeding. Age‐stratification showed that the association of mood disorders with periodontal traits was generally stronger in older group.
Conclusions
Multivariate analysis among discordant monozygotic female twins found mood disorders were independently associated with periodontal traits, suggesting that genetic / early life environmental factors may not explain this association.
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