Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Aline Jelenkovic; Yoon-Mi Hur; Reijo Sund; Yoshie Yokoyama; Sisira H Siribaddana; Matthew Hotopf; Athula Sumathipala; Fruhling Rijsdijk; Qihua Tan; Dongfeng Zhang; Zengchang Pang; Sari Aaltonen; Kauko Heikkilä; Sevgi Y Öncel; Fazil Aliev; Esther Rebato; Adam D Tarnoki; David L Tarnoki; Kaare Christensen; Axel Skytthe; Kirsten O Kyvik; Judy L Silberg; Lindon J Eaves; Hermine H Maes; Tessa L Cutler; John L Hopper; Juan R Ordoñana; Juan F Sánchez-Romera; Lucia Colodro-Conde; Wendy Cozen; Amie E Hwang; Thomas M Mack; Joohon Sung; Yun-Mi Song; Sarah Yang; Kayoung Lee; Carol E Franz; William S Kremen; Michael J Lyons; Andreas Busjahn; Tracy L Nelson; Keith E Whitfield; Christian Kandler; Kerry L Jang; Margaret Gatz; David A Butler; Maria A Stazi; Corrado Fagnani; Cristina D'Ippolito; Glen E Duncan; Dedra Buchwald; Catherine A Derom; Robert F Vlietinck; Ruth JF Loos; Nicholas G Martin; Sarah E Medland; Grant W Montgomery; Hoe-Uk Jeong; Gary E Swan; Ruth Krasnow; Patrik KE Magnusson; Nancy L Pedersen; Anna K Dahl-Aslan; Thomas McAdams; Thalia C Eley; Alice M Gregory; Per Tynelius; Laura A Baker; Catherine Tuvblad; Gombojav Bayasgalan; Danshiitsoodol Narandalai; Paul Lichtenstein; Timothy D Spector; Massimo Mangino; Genevieve Lachance; Meike Bartels; Toos CEM van Beijsterveldt; Gonneke Willemsen; S Alexandra Burt; Kelly L Klump; Jennifer R Harris; Ingunn Brandt; Thomas Sevenius Nilsen; Robert F Krueger; Matt McGue; Shandell Pahlen; Robin P Corley; Jacob v B Hjelmborg; Jack H Goldberg; Yoshinori Iwatani; Mikio Watanabe; Chika Honda; Fujio Inui; Finn Rasmussen; Brooke M Huibregtse; Dorret I Boomsma; Thorkild I A Sørensen; Jaakko Kaprio; Karri Silventoinen; Eduardo Franco

doi:10.7554/eLife.20320

Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Aline Jelenkovic, Yoon-Mi Hur, Reijo Sund, Yoshie Yokoyama, Sisira H Siribaddana, Matthew Hotopf, Athula Sumathipala, Fruhling Rijsdijk, Qihua Tan, Dongfeng Zhang, Zengchang Pang, Sari Aaltonen, Kauko Heikkilä, Sevgi Y Öncel, Fazil Aliev, Esther Rebato, Adam D Tarnoki, David L Tarnoki, Kaare Christensen, Axel SkyttheKirsten O Kyvik, Judy L Silberg, Lindon J Eaves, Hermine H Maes, Tessa L Cutler, John L Hopper, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, Wendy Cozen, Amie E Hwang, Thomas M Mack, Joohon Sung, Yun-Mi Song, Sarah Yang, Kayoung Lee, Carol E Franz, William S Kremen, Michael J Lyons, Andreas Busjahn, Tracy L Nelson, Keith E Whitfield, Christian Kandler, Kerry L Jang, Margaret Gatz, David A Butler, Maria A Stazi, Corrado Fagnani, Cristina D'Ippolito, Glen E Duncan, Dedra Buchwald, Catherine A Derom, Robert F Vlietinck, Ruth JF Loos, Nicholas G Martin, Sarah E Medland, Grant W Montgomery, Hoe-Uk Jeong, Gary E Swan, Ruth Krasnow, Patrik KE Magnusson, Nancy L Pedersen, Anna K Dahl-Aslan, Thomas McAdams, Thalia C Eley, Alice M Gregory, Per Tynelius, Laura A Baker, Catherine Tuvblad, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Paul Lichtenstein, Timothy D Spector, Massimo Mangino, Genevieve Lachance, Meike Bartels, Toos CEM van Beijsterveldt, Gonneke Willemsen, S Alexandra Burt, Kelly L Klump, Jennifer R Harris, Ingunn Brandt, Thomas Sevenius Nilsen, Robert F Krueger, Matt McGue, Shandell Pahlen, Robin P Corley, Jacob v B Hjelmborg, Jack H Goldberg, Yoshinori Iwatani, Mikio Watanabe, Chika Honda, Fujio Inui, Finn Rasmussen, Brooke M Huibregtse, Dorret I Boomsma, Thorkild I A Sørensen, Jaakko Kaprio, Karri Silventoinen, Eduardo Franco (Editor)

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Abstract

Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886–1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.

Original language	English
Pages (from-to)	e20320
Journal	eLife
Volume	5
DOIs	https://doi.org/10.7554/eLife.20320 https://doi.org/10.7554/eLife.20320
Publication status	Published - 14 Dec 2016

Keywords

height
twins
heritability
birth cohorts
CODATwins project

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10.7554/eLife.20320Licence: CC BY
10.7554/eLife.20320

Genetic and environmental influences_JELENKOVIC_Published14December2016_GOLD VoR (CC-BY)Final published version, 431 KBLicence: CC BY

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Jelenkovic, A., Hur, Y.-M., Sund, R., Yokoyama, Y., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Tan, Q., Zhang, D., Pang, Z., Aaltonen, S., Heikkilä, K., Öncel, S. Y., Aliev, F., Rebato, E., Tarnoki, A. D., Tarnoki, D. L., Christensen, K., ... Franco, E. (Ed.) (2016). Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994. eLife, 5, e20320. https://doi.org/10.7554/eLife.20320, https://doi.org/10.7554/eLife.20320

@article{ea09ba3a699745f8839db03c6fa2a4d3,

title = "Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994",

abstract = "Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886–1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.",

keywords = "height, twins, heritability, birth cohorts, CODATwins project",

author = "Aline Jelenkovic and Yoon-Mi Hur and Reijo Sund and Yoshie Yokoyama and Siribaddana, {Sisira H} and Matthew Hotopf and Athula Sumathipala and Fruhling Rijsdijk and Qihua Tan and Dongfeng Zhang and Zengchang Pang and Sari Aaltonen and Kauko Heikkil{\"a} and {\"O}ncel, {Sevgi Y} and Fazil Aliev and Esther Rebato and Tarnoki, {Adam D} and Tarnoki, {David L} and Kaare Christensen and Axel Skytthe and Kyvik, {Kirsten O} and Silberg, {Judy L} and Eaves, {Lindon J} and Maes, {Hermine H} and Cutler, {Tessa L} and Hopper, {John L} and Ordo{\~n}ana, {Juan R} and S{\'a}nchez-Romera, {Juan F} and Lucia Colodro-Conde and Wendy Cozen and Hwang, {Amie E} and Mack, {Thomas M} and Joohon Sung and Yun-Mi Song and Sarah Yang and Kayoung Lee and Franz, {Carol E} and Kremen, {William S} and Lyons, {Michael J} and Andreas Busjahn and Nelson, {Tracy L} and Whitfield, {Keith E} and Christian Kandler and Jang, {Kerry L} and Margaret Gatz and Butler, {David A} and Stazi, {Maria A} and Corrado Fagnani and Cristina D'Ippolito and Duncan, {Glen E} and Dedra Buchwald and Derom, {Catherine A} and Vlietinck, {Robert F} and Loos, {Ruth JF} and Martin, {Nicholas G} and Medland, {Sarah E} and Montgomery, {Grant W} and Hoe-Uk Jeong and Swan, {Gary E} and Ruth Krasnow and Magnusson, {Patrik KE} and Pedersen, {Nancy L} and Dahl-Aslan, {Anna K} and Thomas McAdams and Eley, {Thalia C} and Gregory, {Alice M} and Per Tynelius and Baker, {Laura A} and Catherine Tuvblad and Gombojav Bayasgalan and Danshiitsoodol Narandalai and Paul Lichtenstein and Spector, {Timothy D} and Massimo Mangino and Genevieve Lachance and Meike Bartels and {van Beijsterveldt}, {Toos CEM} and Gonneke Willemsen and Burt, {S Alexandra} and Klump, {Kelly L} and Harris, {Jennifer R} and Ingunn Brandt and Nilsen, {Thomas Sevenius} and Krueger, {Robert F} and Matt McGue and Shandell Pahlen and Corley, {Robin P} and Hjelmborg, {Jacob v B} and Goldberg, {Jack H} and Yoshinori Iwatani and Mikio Watanabe and Chika Honda and Fujio Inui and Finn Rasmussen and Huibregtse, {Brooke M} and Boomsma, {Dorret I} and S{\o}rensen, {Thorkild I A} and Jaakko Kaprio and Karri Silventoinen and Eduardo Franco",

year = "2016",

month = dec,

day = "14",

doi = "10.7554/eLife.20320",

language = "English",

volume = "5",

pages = "e20320",

journal = "eLife",

issn = "2050-084X",

publisher = "eLife Sciences Publications, Ltd",

}

Jelenkovic, A, Hur, Y-M, Sund, R, Yokoyama, Y, Siribaddana, SH, Hotopf, M , Sumathipala, A , Rijsdijk, F, Tan, Q, Zhang, D, Pang, Z, Aaltonen, S, Heikkilä, K, Öncel, SY, Aliev, F, Rebato, E, Tarnoki, AD, Tarnoki, DL, Christensen, K, Skytthe, A, Kyvik, KO, Silberg, JL, Eaves, LJ, Maes, HH, Cutler, TL, Hopper, JL, Ordoñana, JR, Sánchez-Romera, JF, Colodro-Conde, L, Cozen, W, Hwang, AE, Mack, TM, Sung, J, Song, Y-M, Yang, S, Lee, K, Franz, CE, Kremen, WS, Lyons, MJ, Busjahn, A, Nelson, TL, Whitfield, KE, Kandler, C, Jang, KL, Gatz, M, Butler, DA, Stazi, MA, Fagnani, C, D'Ippolito, C, Duncan, GE, Buchwald, D, Derom, CA, Vlietinck, RF, Loos, RJF, Martin, NG, Medland, SE, Montgomery, GW, Jeong, H-U, Swan, GE, Krasnow, R, Magnusson, PKE, Pedersen, NL, Dahl-Aslan, AK, McAdams, T , Eley, TC , Gregory, AM, Tynelius, P, Baker, LA, Tuvblad, C, Bayasgalan, G, Narandalai, D, Lichtenstein, P, Spector, TD, Mangino, M, Lachance, G, Bartels, M, van Beijsterveldt, TCEM, Willemsen, G, Burt, SA, Klump, KL, Harris, JR, Brandt, I, Nilsen, TS, Krueger, RF, McGue, M, Pahlen, S, Corley, RP, Hjelmborg, JVB, Goldberg, JH, Iwatani, Y, Watanabe, M, Honda, C, Inui, F, Rasmussen, F, Huibregtse, BM, Boomsma, DI, Sørensen, TIA, Kaprio, J, Silventoinen, K & Franco, E (ed.) 2016, 'Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994', eLife, vol. 5, pp. e20320. https://doi.org/10.7554/eLife.20320, https://doi.org/10.7554/eLife.20320

TY - JOUR

T1 - Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

AU - Jelenkovic, Aline

AU - Hur, Yoon-Mi

AU - Sund, Reijo

AU - Yokoyama, Yoshie

AU - Siribaddana, Sisira H

AU - Hotopf, Matthew

AU - Sumathipala, Athula

AU - Rijsdijk, Fruhling

AU - Tan, Qihua

AU - Zhang, Dongfeng

AU - Pang, Zengchang

AU - Aaltonen, Sari

AU - Heikkilä, Kauko

AU - Öncel, Sevgi Y

AU - Aliev, Fazil

AU - Rebato, Esther

AU - Tarnoki, Adam D

AU - Tarnoki, David L

AU - Christensen, Kaare

AU - Skytthe, Axel

AU - Kyvik, Kirsten O

AU - Silberg, Judy L

AU - Eaves, Lindon J

AU - Maes, Hermine H

AU - Cutler, Tessa L

AU - Hopper, John L

AU - Ordoñana, Juan R

AU - Sánchez-Romera, Juan F

AU - Colodro-Conde, Lucia

AU - Cozen, Wendy

AU - Hwang, Amie E

AU - Mack, Thomas M

AU - Sung, Joohon

AU - Song, Yun-Mi

AU - Yang, Sarah

AU - Lee, Kayoung

AU - Franz, Carol E

AU - Kremen, William S

AU - Lyons, Michael J

AU - Busjahn, Andreas

AU - Nelson, Tracy L

AU - Whitfield, Keith E

AU - Kandler, Christian

AU - Jang, Kerry L

AU - Gatz, Margaret

AU - Butler, David A

AU - Stazi, Maria A

AU - Fagnani, Corrado

AU - D'Ippolito, Cristina

AU - Duncan, Glen E

AU - Buchwald, Dedra

AU - Derom, Catherine A

AU - Vlietinck, Robert F

AU - Loos, Ruth JF

AU - Martin, Nicholas G

AU - Medland, Sarah E

AU - Montgomery, Grant W

AU - Jeong, Hoe-Uk

AU - Swan, Gary E

AU - Krasnow, Ruth

AU - Magnusson, Patrik KE

AU - Pedersen, Nancy L

AU - Dahl-Aslan, Anna K

AU - McAdams, Thomas

AU - Eley, Thalia C

AU - Gregory, Alice M

AU - Tynelius, Per

AU - Baker, Laura A

AU - Tuvblad, Catherine

AU - Bayasgalan, Gombojav

AU - Narandalai, Danshiitsoodol

AU - Lichtenstein, Paul

AU - Spector, Timothy D

AU - Mangino, Massimo

AU - Lachance, Genevieve

AU - Bartels, Meike

AU - van Beijsterveldt, Toos CEM

AU - Willemsen, Gonneke

AU - Burt, S Alexandra

AU - Klump, Kelly L

AU - Harris, Jennifer R

AU - Brandt, Ingunn

AU - Nilsen, Thomas Sevenius

AU - Krueger, Robert F

AU - McGue, Matt

AU - Pahlen, Shandell

AU - Corley, Robin P

AU - Hjelmborg, Jacob v B

AU - Goldberg, Jack H

AU - Iwatani, Yoshinori

AU - Watanabe, Mikio

AU - Honda, Chika

AU - Inui, Fujio

AU - Rasmussen, Finn

AU - Huibregtse, Brooke M

AU - Boomsma, Dorret I

AU - Sørensen, Thorkild I A

AU - Kaprio, Jaakko

AU - Silventoinen, Karri

A2 - Franco, Eduardo

PY - 2016/12/14

Y1 - 2016/12/14

N2 - Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886–1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.

AB - Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886–1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.

KW - height

KW - twins

KW - heritability

KW - birth cohorts

KW - CODATwins project

U2 - 10.7554/eLife.20320

DO - 10.7554/eLife.20320

M3 - Article

SN - 2050-084X

VL - 5

SP - e20320

JO - eLife

JF - eLife

ER -

Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

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