This chapter first provides an overview of the influences on the manifestation of disruptive behavior disorders (DBDs) in children and adolescents, with a focus on conduct disorder (CD) and oppositional defiant disorder (ODD). Next, it reviews molecular genetic approaches—including candidate gene (hypothesis‐driven) and genome‐wide (hypothesis‐free) studies. The chapter further examines studies of gene‐environment (G×E) interplay. G×E interactions occur when an environmental influence on a trait or phenotype is dependent on an individual's genotype, or when an individual's genetic predispositions are expressed differently under distinct environmental conditions. Theoretical underpinnings of G×E have most often been articulated within the diathesis‐stress model, whereby genetic vulnerability (or diathesis) for phenotype is activated or exacerbated in the presence of certain environmental stressors. The chapter closes with a discussion on current challenges and proposes some key ways to move the area forward in the future.
|Title of host publication||The Wiley Handbook of Disruptive and Impulse-Control Disorders|
|Editors||John E. Lochman, Walter Matthys|
|Publisher||John Wiley & Sons, Ltd|
|Publication status||Published - 30 Oct 2017|