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Genetic and Gene-Environment Influences on Disruptive Behavior Disorders

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish
Title of host publicationThe Wiley Handbook of Disruptive and Impulse-Control Disorders
EditorsJohn E. Lochman, Walter Matthys
PublisherJohn Wiley & Sons, Ltd
ISBN (Electronic)9781119092254
ISBN (Print)9781119092162
E-pub ahead of print21 Aug 2017
Published30 Oct 2017

King's Authors


This chapter first provides an overview of the influences on the manifestation of disruptive behavior disorders (DBDs) in children and adolescents, with a focus on conduct disorder (CD) and oppositional defiant disorder (ODD). Next, it reviews molecular genetic approaches—including candidate gene (hypothesis‐driven) and genome‐wide (hypothesis‐free) studies. The chapter further examines studies of gene‐environment (G×E) interplay. G×E interactions occur when an environmental influence on a trait or phenotype is dependent on an individual's genotype, or when an individual's genetic predispositions are expressed differently under distinct environmental conditions. Theoretical underpinnings of G×E have most often been articulated within the diathesis‐stress model, whereby genetic vulnerability (or diathesis) for phenotype is activated or exacerbated in the presence of certain environmental stressors. The chapter closes with a discussion on current challenges and proposes some key ways to move the area forward in the future.

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