Genetic Associations of Autopsy-Confirmed Vascular Dementia Subtypes

Emma L. Jones; Rajesh N. Kalaria; Sally I. Sharp; John T. O&apos;Brien; Paul T. Francis; Clive G. Ballard

doi:10.1159/000327171

Genetic Associations of Autopsy-Confirmed Vascular Dementia Subtypes

Emma L. Jones, Rajesh N. Kalaria, Sally I. Sharp, John T. O'Brien, Paul T. Francis, Clive G. Ballard

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Background/Aims: Genetic risk factors have not been clearly established for vascular dementias (VaD) related to stroke and cerebrovascular disease. Methods: Samples were genotyped for APOE, MTHFR and ICAM. A beta levels and choline acetyltransferase (ChAT) activities were assayed in controls and individuals with VaD. Results: Associations were found between the APOE-epsilon 4 allele and mixed dementia, infarct/stroke dementia and subcortical ischemic vascular dementia (SIVD), and higher A beta 1-42 levels and decreased ChAT activity. MTHFR was more associated with SIVD, mixed dementia, and lower ChAT activity. Conclusions: The study demonstrates important differences in the genetic associations of VaD and begins to clarify the genetic basis of key pathological substrates. Copyright (C) 2011 S. Karger AG, Basel

Original language	English
Pages (from-to)	247 - 253
Number of pages	7
Journal	Dementia and Geriatric Cognitive Disorders
Volume	31
Issue number	4
DOIs	https://doi.org/10.1159/000327171
Publication status	Published - May 2011

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title = "Genetic Associations of Autopsy-Confirmed Vascular Dementia Subtypes",

abstract = "Background/Aims: Genetic risk factors have not been clearly established for vascular dementias (VaD) related to stroke and cerebrovascular disease. Methods: Samples were genotyped for APOE, MTHFR and ICAM. A beta levels and choline acetyltransferase (ChAT) activities were assayed in controls and individuals with VaD. Results: Associations were found between the APOE-epsilon 4 allele and mixed dementia, infarct/stroke dementia and subcortical ischemic vascular dementia (SIVD), and higher A beta 1-42 levels and decreased ChAT activity. MTHFR was more associated with SIVD, mixed dementia, and lower ChAT activity. Conclusions: The study demonstrates important differences in the genetic associations of VaD and begins to clarify the genetic basis of key pathological substrates. Copyright (C) 2011 S. Karger AG, Basel",

author = "Jones, {Emma L.} and Kalaria, {Rajesh N.} and Sharp, {Sally I.} and O'Brien, {John T.} and Francis, {Paul T.} and Ballard, {Clive G.}",

year = "2011",

month = may,

doi = "10.1159/000327171",

language = "English",

volume = "31",

pages = "247 -- 253",

journal = "Dementia and Geriatric Cognitive Disorders",

publisher = "S. Karger AG",

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TY - JOUR

T1 - Genetic Associations of Autopsy-Confirmed Vascular Dementia Subtypes

AU - Jones, Emma L.

AU - Kalaria, Rajesh N.

AU - Sharp, Sally I.

AU - O'Brien, John T.

AU - Francis, Paul T.

AU - Ballard, Clive G.

PY - 2011/5

Y1 - 2011/5

N2 - Background/Aims: Genetic risk factors have not been clearly established for vascular dementias (VaD) related to stroke and cerebrovascular disease. Methods: Samples were genotyped for APOE, MTHFR and ICAM. A beta levels and choline acetyltransferase (ChAT) activities were assayed in controls and individuals with VaD. Results: Associations were found between the APOE-epsilon 4 allele and mixed dementia, infarct/stroke dementia and subcortical ischemic vascular dementia (SIVD), and higher A beta 1-42 levels and decreased ChAT activity. MTHFR was more associated with SIVD, mixed dementia, and lower ChAT activity. Conclusions: The study demonstrates important differences in the genetic associations of VaD and begins to clarify the genetic basis of key pathological substrates. Copyright (C) 2011 S. Karger AG, Basel

AB - Background/Aims: Genetic risk factors have not been clearly established for vascular dementias (VaD) related to stroke and cerebrovascular disease. Methods: Samples were genotyped for APOE, MTHFR and ICAM. A beta levels and choline acetyltransferase (ChAT) activities were assayed in controls and individuals with VaD. Results: Associations were found between the APOE-epsilon 4 allele and mixed dementia, infarct/stroke dementia and subcortical ischemic vascular dementia (SIVD), and higher A beta 1-42 levels and decreased ChAT activity. MTHFR was more associated with SIVD, mixed dementia, and lower ChAT activity. Conclusions: The study demonstrates important differences in the genetic associations of VaD and begins to clarify the genetic basis of key pathological substrates. Copyright (C) 2011 S. Karger AG, Basel

U2 - 10.1159/000327171

DO - 10.1159/000327171

M3 - Article

VL - 31

SP - 247

EP - 253

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

IS - 4

ER -

Genetic Associations of Autopsy-Confirmed Vascular Dementia Subtypes

Abstract

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