TY - JOUR
T1 - Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent
AU - Huebel, Christopher
AU - Gaspar, Héléna Alexandra
AU - Coleman, Jonathan Richard Iain
AU - Hanscombe, Ken Benjamin
AU - Eating Disorders Working Group of the Psychiatric Genomics Consortium
AU - Purves, Kirstin
AU - Prokopenko, Inga
AU - The MAGIC Investigators
AU - O'Reilly, Paul Francis
AU - Bulik, Cynthia M.
AU - Breen, Gerome Daniel
PY - 2019
Y1 - 2019
N2 - Body composition is often altered in psychiatric disorders. Using genomewide common genetic variation data, we calculate sex-specific genetic correlations amongst body fat %, fat mass, fat-free mass, physical activity, glycemic traits and 17 psychiatric traits (up to N = 217,568). Two patterns emerge: (1) anorexia nervosa, schizophrenia, obsessive-compulsive disorder, and education years are negatively genetically correlated with body fat % and fat-free mass, whereas (2) attention-deficit/hyperactivity disorder (ADHD), alcohol dependence, insomnia, and heavy smoking are positively correlated. Anorexia nervosa shows a stronger genetic correlation with body fat % in females, whereas education years is more strongly correlated with fat mass in males. Education years and ADHD show genetic overlap with childhood obesity. Mendelian randomization identifies schizophrenia, anorexia nervosa, and higher education as causal for decreased fat mass, with higher body fat % possibly being a causal risk factor for ADHD and heavy smoking. These results suggest new possibilities for targeted preventive strategies.
AB - Body composition is often altered in psychiatric disorders. Using genomewide common genetic variation data, we calculate sex-specific genetic correlations amongst body fat %, fat mass, fat-free mass, physical activity, glycemic traits and 17 psychiatric traits (up to N = 217,568). Two patterns emerge: (1) anorexia nervosa, schizophrenia, obsessive-compulsive disorder, and education years are negatively genetically correlated with body fat % and fat-free mass, whereas (2) attention-deficit/hyperactivity disorder (ADHD), alcohol dependence, insomnia, and heavy smoking are positively correlated. Anorexia nervosa shows a stronger genetic correlation with body fat % in females, whereas education years is more strongly correlated with fat mass in males. Education years and ADHD show genetic overlap with childhood obesity. Mendelian randomization identifies schizophrenia, anorexia nervosa, and higher education as causal for decreased fat mass, with higher body fat % possibly being a causal risk factor for ADHD and heavy smoking. These results suggest new possibilities for targeted preventive strategies.
UR - http://www.scopus.com/inward/record.url?scp=85076909422&partnerID=8YFLogxK
U2 - 10.1038/s41467-019-13544-0
DO - 10.1038/s41467-019-13544-0
M3 - Article
SN - 2041-1723
VL - 10
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5765
ER -