TY - JOUR
T1 - Genetic determinants of bone density and fracture risk - State of the art and future directions
AU - Duncan, Emma L.
AU - Brown, Matthew A.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2010/6
Y1 - 2010/6
N2 - Context: Osteoporosis is a common, highly heritable condition that causes substantial morbidity and mortality, the etiopathogenesis of which is poorly understood. Genetic studies are making increasingly rapid progress in identifying the genes involved. Evidence Acquisition and Synthesis: In this review, we will summarize the current understanding of the genetics of osteoporosis based on publications from PubMed from the year 1987 onward. Conclusions: Most genes involved in osteoporosis identified to date encode components of known pathways involved in bone synthesis or resorption, but as the field progresses, new pathways are being identified. Only a small proportion of the total genetic variation involved in osteoporosis has been identified, and new approaches will be required to identify most of the remaining genes.
AB - Context: Osteoporosis is a common, highly heritable condition that causes substantial morbidity and mortality, the etiopathogenesis of which is poorly understood. Genetic studies are making increasingly rapid progress in identifying the genes involved. Evidence Acquisition and Synthesis: In this review, we will summarize the current understanding of the genetics of osteoporosis based on publications from PubMed from the year 1987 onward. Conclusions: Most genes involved in osteoporosis identified to date encode components of known pathways involved in bone synthesis or resorption, but as the field progresses, new pathways are being identified. Only a small proportion of the total genetic variation involved in osteoporosis has been identified, and new approaches will be required to identify most of the remaining genes.
UR - http://www.scopus.com/inward/record.url?scp=77954526395&partnerID=8YFLogxK
U2 - 10.1210/jc.2009-2406
DO - 10.1210/jc.2009-2406
M3 - Review article
C2 - 20375209
AN - SCOPUS:77954526395
SN - 0021-972X
VL - 95
SP - 2576
EP - 2587
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 6
ER -