Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

S. A. Fisher; M. Tremelling; C. A. Anderson; R. Gwilliam; S. Bumpstead; N. J. Prescott; E. R. Nimmo; D. Massey; C. Berzuini; C. Johnson; J. C. Barrett; F. R. Cummings; H. Drummond; C. W. Lees; C. M. Onnie; C. E. Hanson; K. Blaszczyk; M. Inouye; P. Ewels; R. Ravindrarajah; A. Keniry; S. Hunt; M. Carter; N. Watkins; W. Ouwehand; C. M. Lewis; L. Cardon; The Wellcome Trust Case Control Consortium; A. Lobo; A. Forbes; J. Sanderson; D. P. Jewell; J. C. Mansfield; P. Deloukas; C. G. Mathew; M. Parkes; J. Satsangi

doi:10.1038/ng.145

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

S. A. Fisher, M. Tremelling, C. A. Anderson, R. Gwilliam, S. Bumpstead, N. J. Prescott, E. R. Nimmo, D. Massey, C. Berzuini, C. Johnson, J. C. Barrett, F. R. Cummings, H. Drummond, C. W. Lees, C. M. Onnie, C. E. Hanson, K. Blaszczyk, M. Inouye, P. Ewels, R. RavindrarajahA. Keniry, S. Hunt, M. Carter, N. Watkins, W. Ouwehand, C. M. Lewis, L. Cardon, The Wellcome Trust Case Control Consortium, A. Lobo, A. Forbes, J. Sanderson, D. P. Jewell, J. C. Mansfield, P. Deloukas, C. G. Mathew, M. Parkes, J. Satsangi

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Abstract

We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases.

Original language	English
Pages (from-to)	710-712
Number of pages	3
Journal	Nature Genetics
Volume	40
Issue number	6
DOIs	https://doi.org/10.1038/ng.145
Publication status	Published - Jun 2008

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Fisher, S. A., Tremelling, M., Anderson, C. A., Gwilliam, R., Bumpstead, S., Prescott, N. J., Nimmo, E. R., Massey, D., Berzuini, C., Johnson, C., Barrett, J. C., Cummings, F. R., Drummond, H., Lees, C. W., Onnie, C. M., Hanson, C. E., Blaszczyk, K., Inouye, M., Ewels, P., ... Satsangi, J. (2008). Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nature Genetics, 40(6), 710-712. https://doi.org/10.1038/ng.145

@article{5f179b03cc8949a59158b292dbc28052,

title = "Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease",

abstract = "We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases.",

author = "Fisher, {S. A.} and M. Tremelling and Anderson, {C. A.} and R. Gwilliam and S. Bumpstead and Prescott, {N. J.} and Nimmo, {E. R.} and D. Massey and C. Berzuini and C. Johnson and Barrett, {J. C.} and Cummings, {F. R.} and H. Drummond and Lees, {C. W.} and Onnie, {C. M.} and Hanson, {C. E.} and K. Blaszczyk and M. Inouye and P. Ewels and R. Ravindrarajah and A. Keniry and S. Hunt and M. Carter and N. Watkins and W. Ouwehand and Lewis, {C. M.} and L. Cardon and {The Wellcome Trust Case Control Consortium} and A. Lobo and A. Forbes and J. Sanderson and Jewell, {D. P.} and Mansfield, {J. C.} and P. Deloukas and Mathew, {C. G.} and M. Parkes and J. Satsangi and Gerome Breen",

year = "2008",

month = jun,

doi = "10.1038/ng.145",

language = "English",

volume = "40",

pages = "710--712",

journal = "Nature Genetics",

issn = "1546-1718",

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Fisher, SA, Tremelling, M, Anderson, CA, Gwilliam, R, Bumpstead, S, Prescott, NJ, Nimmo, ER, Massey, D, Berzuini, C, Johnson, C, Barrett, JC, Cummings, FR, Drummond, H, Lees, CW, Onnie, CM, Hanson, CE, Blaszczyk, K, Inouye, M, Ewels, P, Ravindrarajah, R, Keniry, A, Hunt, S, Carter, M, Watkins, N, Ouwehand, W, Lewis, CM, Cardon, L, The Wellcome Trust Case Control Consortium, Lobo, A, Forbes, A, Sanderson, J, Jewell, DP, Mansfield, JC, Deloukas, P, Mathew, CG, Parkes, M & Satsangi, J 2008, 'Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease', Nature Genetics, vol. 40, no. 6, pp. 710-712. https://doi.org/10.1038/ng.145

TY - JOUR

T1 - Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

AU - Fisher, S. A.

AU - Tremelling, M.

AU - Anderson, C. A.

AU - Gwilliam, R.

AU - Bumpstead, S.

AU - Prescott, N. J.

AU - Nimmo, E. R.

AU - Massey, D.

AU - Berzuini, C.

AU - Johnson, C.

AU - Barrett, J. C.

AU - Cummings, F. R.

AU - Drummond, H.

AU - Lees, C. W.

AU - Onnie, C. M.

AU - Hanson, C. E.

AU - Blaszczyk, K.

AU - Inouye, M.

AU - Ewels, P.

AU - Ravindrarajah, R.

AU - Keniry, A.

AU - Hunt, S.

AU - Carter, M.

AU - Watkins, N.

AU - Ouwehand, W.

AU - Lewis, C. M.

AU - Cardon, L.

AU - The Wellcome Trust Case Control Consortium

AU - Lobo, A.

AU - Forbes, A.

AU - Sanderson, J.

AU - Jewell, D. P.

AU - Mansfield, J. C.

AU - Deloukas, P.

AU - Mathew, C. G.

AU - Parkes, M.

AU - Satsangi, J.

AU - Breen, Gerome

PY - 2008/6

Y1 - 2008/6

N2 - We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases.

AB - We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases.

U2 - 10.1038/ng.145

DO - 10.1038/ng.145

M3 - Article

SN - 1546-1718

VL - 40

SP - 710

EP - 712

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

Abstract

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