Genetic imaging consortium for addiction medicine: From neuroimaging to genes

Scott Mackey, Kees Jan Kan, Bader Chaarani, Nelly Alia-Klein, Albert Batalla, Samantha Brooks, Janna Cousijn , Alain Dagher, Michiel de Ruiter , Sylvane Desrivieres, Sarah W. Feldstein Ewing , Rita Z. Goldstein, Anna E. Goudriaan , Mary M. Heitzeg , Kent Hutchison , Chiang-Shan R. Li , Edythe D. London , Valentina Lorenzetti, Maartje Luijten , Rocio Martin-SantosAngelica M. Morales, Martin P. Paulus , Tomas Paus, Godfrey Pearlson, Renée Schluter , Reza Momenan , Lianne Schmaal, Gunter Schumann, Rajita Sinha , Zsuzsika Sjoerds , Dan J. Stein, Elliot A. Stein, Nadia Solowij, Susan Tapert , Anne Uhlmann , Dick J. Veltman, Ruth van Holst , Henrik Walter, Margaret J. Wright, Murat Yücel, Deborah A. Yurgelun-Todd, Derrek P. Hibar, Neda Jahanshad, Paul M. Thompson, David C. Glahn, Hugh Garavan, Patricia Conrod

Research output: Contribution to journalLiterature reviewpeer-review

21 Citations (Scopus)


Since the sample size of a typical neuroimaging study lacks sufficient statistical power to explore unknown genomic associations with brain phenotypes, several international genetic imaging consortia have been organized in recent years to pool data across sites. The challenges and achievements of these consortia are considered here with the goal of leveraging these resources to study addiction.

The authors of this review have joined together to form an Addiction working group within the framework of the ENIGMA project, a meta-analytic approach to multisite genetic imaging data. Collectively, the Addiction working group possesses neuroimaging and genomic data obtained from over 10,000 subjects. The deadline for contributing data to the first round of analyses occurred at the beginning of May 2015. The studies performed on this data should significantly impact our understanding of the genetic and neurobiological basis of addiction.
Original languageEnglish
Pages (from-to)203–223
JournalProgress in Brain Research
Publication statusE-pub ahead of print - 4 Nov 2015


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