Abstract
Cancer genomes acquire somatic alterations that largely differ between and within cancer types. Several of these alterations inactivate genes that are normally functional with no deleterious consequences on cancer cells due to genetic redundancy. Here we discuss how this leads to cancer synthetic dependencies that can be exploited in therapy.
Original language | English |
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Journal | Trends in Cancer |
DOIs | |
Publication status | E-pub ahead of print - 28 Mar 2016 |
Keywords
- functional redundancy
- paralog dependency
- cancer genomics
- synthetic lethality
- personalized medicine