Genetic Redundancy, Functional Compensation, and Cancer Vulnerability

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)
    169 Downloads (Pure)

    Abstract

    Cancer genomes acquire somatic alterations that largely differ between and within cancer types. Several of these alterations inactivate genes that are normally functional with no deleterious consequences on cancer cells due to genetic redundancy. Here we discuss how this leads to cancer synthetic dependencies that can be exploited in therapy.
    Original languageEnglish
    JournalTrends in Cancer
    DOIs
    Publication statusE-pub ahead of print - 28 Mar 2016

    Keywords

    • functional redundancy
    • paralog dependency
    • cancer genomics
    • synthetic lethality
    • personalized medicine

    Fingerprint

    Dive into the research topics of 'Genetic Redundancy, Functional Compensation, and Cancer Vulnerability'. Together they form a unique fingerprint.

    Cite this