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Genetic Redundancy, Functional Compensation, and Cancer Vulnerability

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
JournalTrends in Cancer
E-pub ahead of print28 Mar 2016


  • Ciccarelli_Main_AAM

    Ciccarelli_Main_rev.docx, 56.9 KB, application/vnd.openxmlformats-officedocument.wordprocessingml.document

    Uploaded date:18 May 2016

    Version:Accepted author manuscript

King's Authors


Cancer genomes acquire somatic alterations that largely differ between and within cancer types. Several of these alterations inactivate genes that are normally functional with no deleterious consequences on cancer cells due to genetic redundancy. Here we discuss how this leads to cancer synthetic dependencies that can be exploited in therapy.

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