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Genetic Redundancy, Functional Compensation, and Cancer Vulnerability

Research output: Contribution to journalArticle

Original languageEnglish
JournalTrends in Cancer
DOIs
StateE-pub ahead of print - 28 Mar 2016

Documents

  • Ciccarelli_Main_AAM

    Ciccarelli_Main_rev.docx, 56 KB, application/vnd.openxmlformats-officedocument.wordprocessingml.document

    28/03/2017

    Accepted author manuscript

King's Authors

Abstract

Cancer genomes acquire somatic alterations that largely differ between and within cancer types. Several of these alterations inactivate genes that are normally functional with no deleterious consequences on cancer cells due to genetic redundancy. Here we discuss how this leads to cancer synthetic dependencies that can be exploited in therapy.

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