@article{aebedec3453e4cb29a1df86f0c8576ae,
title = "Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs",
abstract = "Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 ± 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 ± 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 ± 0.06 s.e.), and ADHD and major depressive disorder (0.32 ± 0.07 s.e.), low between schizophrenia and ASD (0.16 ± 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.",
keywords = "Acknowledged-BRC, Acknowledged-BRC-13/14",
author = "Lee, {S Hong} and Stephan Ripke and Neale, {Benjamin M} and Faraone, {Stephen V} and Purcell, {Shaun M} and Perlis, {Roy H} and Mowry, {Bryan J} and Anita Thapar and Goddard, {Michael E} and Witte, {John S} and Devin Absher and Ingrid Agartz and Huda Akil and Farooq Amin and Andreassen, {Ole A} and Adebayo Anjorin and Richard Anney and Verneri Anttila and Arking, {Dan E} and Philip Asherson and Azevedo, {Maria H} and Lena Backlund and Badner, {Judith A} and Bailey, {Anthony J} and Tobias Banaschewski and Barchas, {Jack D} and Barnes, {Michael R} and Barrett, {Thomas B} and Nicholas Bass and Agatino Battaglia and Michael Bauer and M{\`o}nica Bay{\'e}s and Frank Bellivier and Bergen, {Sarah E} and Wade Berrettini and Gerome Breen and Collier, {David A} and Craig, {David W} and Craig, {Ian W} and Richard Day and Farmer, {Anne E} and Eric Fombonne and Freitag, {Christine M} and Jonna Kuntsi and Lewis, {Cathryn M} and Lowe, {Jennifer K} and Peter McGuffin and Parr, {Jeremy R} and Sonuga-Barke, {Edmund J S} and Young, {Allan H} and {Cross-Disorder Group of the Psychiatric Genomics Consortium}",
year = "2013",
month = sep,
doi = "10.1038/ng.2711",
language = "English",
volume = "45",
pages = "984--994",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Research",
number = "9",
}