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Genetic risk factors for eating disorders: an update and insights into pathophysiology

Research output: Contribution to journalArticle

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Genetic risk factors for eating disorders: an update and insights into pathophysiology. / Himmerich, Hubertus; Bentley, Jessica; Kan, Carol; Treasure, Janet Linda.

In: Therapeutic Advances in Psychopharmacology, 29.10.2018.

Research output: Contribution to journalArticle

Harvard

Himmerich, H, Bentley, J, Kan, C & Treasure, JL 2018, 'Genetic risk factors for eating disorders: an update and insights into pathophysiology', Therapeutic Advances in Psychopharmacology.

APA

Himmerich, H., Bentley, J., Kan, C., & Treasure, J. L. (Accepted/In press). Genetic risk factors for eating disorders: an update and insights into pathophysiology. Therapeutic Advances in Psychopharmacology.

Vancouver

Himmerich H, Bentley J, Kan C, Treasure JL. Genetic risk factors for eating disorders: an update and insights into pathophysiology. Therapeutic Advances in Psychopharmacology. 2018 Oct 29.

Author

Himmerich, Hubertus ; Bentley, Jessica ; Kan, Carol ; Treasure, Janet Linda. / Genetic risk factors for eating disorders: an update and insights into pathophysiology. In: Therapeutic Advances in Psychopharmacology. 2018.

Bibtex Download

@article{48f70a98ee1a40caaae042dd66d184d1,
title = "Genetic risk factors for eating disorders: an update and insights into pathophysiology",
abstract = "Genome-wide association studies (GWAS), epigenetic, gene-expression and gene-gene interaction projects, nutritional genomics and investigations of the gut microbiota have increased our knowledge of the pathophysiology of eating disorders (EDs). However, compared with anorexia nervosa, genetic studies in patients with bulimia nervosa and binge-eating disorder are relatively scarce, with the exception of a few formal genetic and small-sized candidate-gene association studies.In this article, we review important findings derived from formal and molecular genetics in order to outline a genetics-based pathophysiological model of EDs. This model takes into account environmental and nutritional factors, genetic factors related to the microbiome, the metabolic and endocrine system, the immune system, and the brain, in addition to phenotypical traits of EDs. Shortcomings and advantages of genetic research in EDs are discussed against the historical background, but also in light of potential future treatment options for patients with EDs.",
author = "Hubertus Himmerich and Jessica Bentley and Carol Kan and Treasure, {Janet Linda}",
year = "2018",
month = oct,
day = "29",
language = "English",
journal = "Therapeutic Advances in Psychopharmacology",
issn = "2045-1253",
publisher = "Sage Publications",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Genetic risk factors for eating disorders: an update and insights into pathophysiology

AU - Himmerich, Hubertus

AU - Bentley, Jessica

AU - Kan, Carol

AU - Treasure, Janet Linda

PY - 2018/10/29

Y1 - 2018/10/29

N2 - Genome-wide association studies (GWAS), epigenetic, gene-expression and gene-gene interaction projects, nutritional genomics and investigations of the gut microbiota have increased our knowledge of the pathophysiology of eating disorders (EDs). However, compared with anorexia nervosa, genetic studies in patients with bulimia nervosa and binge-eating disorder are relatively scarce, with the exception of a few formal genetic and small-sized candidate-gene association studies.In this article, we review important findings derived from formal and molecular genetics in order to outline a genetics-based pathophysiological model of EDs. This model takes into account environmental and nutritional factors, genetic factors related to the microbiome, the metabolic and endocrine system, the immune system, and the brain, in addition to phenotypical traits of EDs. Shortcomings and advantages of genetic research in EDs are discussed against the historical background, but also in light of potential future treatment options for patients with EDs.

AB - Genome-wide association studies (GWAS), epigenetic, gene-expression and gene-gene interaction projects, nutritional genomics and investigations of the gut microbiota have increased our knowledge of the pathophysiology of eating disorders (EDs). However, compared with anorexia nervosa, genetic studies in patients with bulimia nervosa and binge-eating disorder are relatively scarce, with the exception of a few formal genetic and small-sized candidate-gene association studies.In this article, we review important findings derived from formal and molecular genetics in order to outline a genetics-based pathophysiological model of EDs. This model takes into account environmental and nutritional factors, genetic factors related to the microbiome, the metabolic and endocrine system, the immune system, and the brain, in addition to phenotypical traits of EDs. Shortcomings and advantages of genetic research in EDs are discussed against the historical background, but also in light of potential future treatment options for patients with EDs.

M3 - Article

JO - Therapeutic Advances in Psychopharmacology

JF - Therapeutic Advances in Psychopharmacology

SN - 2045-1253

ER -

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