Genetic studies in osteoporosis - The end of the beginning

TY - JOUR

T1 - Genetic studies in osteoporosis - The end of the beginning

AU - Duncan, Emma L.

AU - Brown, Matthew A.

N1 - Copyright: Copyright 2009 Elsevier B.V., All rights reserved.

PY - 2008/9/12

Y1 - 2008/9/12

N2 - Osteoporosis and disorders of bone fragility are highly heritable, but despite much effort the identities of few of the genes involved has been established. Recent developments in genetics such as genome-wide association studies are revolutionizing research in this field, and it is likely that further contributions will be made through application of next-generation sequencing technologies, analysis of copy number variation polymorphisms, and high-throughput mouse mutagenesis programs. This article outlines what we know about osteoporosis genetics to date and the probable future directions of research in this field.

AB - Osteoporosis and disorders of bone fragility are highly heritable, but despite much effort the identities of few of the genes involved has been established. Recent developments in genetics such as genome-wide association studies are revolutionizing research in this field, and it is likely that further contributions will be made through application of next-generation sequencing technologies, analysis of copy number variation polymorphisms, and high-throughput mouse mutagenesis programs. This article outlines what we know about osteoporosis genetics to date and the probable future directions of research in this field.

UR - http://www.scopus.com/inward/record.url?scp=60549099974&partnerID=8YFLogxK

U2 - 10.1186/ar2479

DO - 10.1186/ar2479

M3 - Review article

C2 - 18828878

AN - SCOPUS:60549099974

SN - 1478-6354

VL - 10

JO - Arthritis Research and Therapy

JF - Arthritis Research and Therapy

IS - 5

M1 - 214

ER -