Genetic studies of amyotrophic lateral sclerosis: Controversies and perspectives

Ana Beleza-Meireles; Ammar Al-Chalabi

doi:10.1080/17482960802585469

Genetic studies of amyotrophic lateral sclerosis: Controversies and perspectives

Ana Beleza-Meireles, Ammar Al-Chalabi

Research output: Contribution to journal › Literature review › peer-review

87 Citations (Scopus)

Abstract

The genetic causes of amyotrophic lateral sclerosis (ALS) are slowly being dissected out with the help of recent advances in genetic technology. Linkage studies and association studies examining candidate genes, candidate pathways, and genome-wide association have been used, based on direct sequencing and correlations between genetic variations. Copy number and microsatellite variants have also been examined, although the ideal methods for analysis are still being developed. In this review we examine the evidence for a genetic basis to ALS, discuss the challenges and difficulties faced and summarize the support for the reported genetic causes of ALS.

Original language	English
Pages (from-to)	1 - 14
Number of pages	14
Journal	Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
Volume	10
Issue number	1
DOIs	https://doi.org/10.1080/17482960802585469
Publication status	Published - 2009

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abstract = "The genetic causes of amyotrophic lateral sclerosis (ALS) are slowly being dissected out with the help of recent advances in genetic technology. Linkage studies and association studies examining candidate genes, candidate pathways, and genome-wide association have been used, based on direct sequencing and correlations between genetic variations. Copy number and microsatellite variants have also been examined, although the ideal methods for analysis are still being developed. In this review we examine the evidence for a genetic basis to ALS, discuss the challenges and difficulties faced and summarize the support for the reported genetic causes of ALS.",

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AB - The genetic causes of amyotrophic lateral sclerosis (ALS) are slowly being dissected out with the help of recent advances in genetic technology. Linkage studies and association studies examining candidate genes, candidate pathways, and genome-wide association have been used, based on direct sequencing and correlations between genetic variations. Copy number and microsatellite variants have also been examined, although the ideal methods for analysis are still being developed. In this review we examine the evidence for a genetic basis to ALS, discuss the challenges and difficulties faced and summarize the support for the reported genetic causes of ALS.

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Genetic studies of amyotrophic lateral sclerosis: Controversies and perspectives

Abstract

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