Genetic validation of psoriasis phenotyping in UK Biobank supports the utility of self-reported data and composite definitions for large genetic and epidemiological studies

TY - JOUR

T1 - Genetic validation of psoriasis phenotyping in UK Biobank supports the utility of self-reported data and composite definitions for large genetic and epidemiological studies

AU - Saklatvala, Jake R

AU - Hanscombe, Ken B

AU - Mahil, Satveer K

AU - Tsoi, Lam C

AU - Elder, James T

AU - Barker, Jonathan N

AU - Simpson, Michael A

AU - Smith, Catherine H

AU - Dand, Nick

N1 - Funding Information: This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement number 821511 (Biomarkers in Atopic Dermatitis and Psoriasis). The JU receives support from the European Union’s Horizon 2020 research and innovation program and the European Federation of Pharmaceutical Industries and Associations. This publication reflects only the author's view and the JU is not responsible for any use that may be made of the information it contains. This research has been conducted using the UK Biobank resource (approved project 15147) and uses data provided by patients and collected by the NHS as part of their care and support. ND received funding from Health Data Research UK (MR/S003126/1), which is funded by the UK Medical Research Council , Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation, and the Wellcome Trust. SKM is funded by an MRC Clinical Academic Research Partnership Award ( MR/T02383X/1 ). Funding Information: This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement number 821511 (Biomarkers in Atopic Dermatitis and Psoriasis). The JU receives support from the European Union's Horizon 2020 research and innovation program and the European Federation of Pharmaceutical Industries and Associations. This publication reflects only the author's view and the JU is not responsible for any use that may be made of the information it contains. This research has been conducted using the UK Biobank resource (approved project 15147) and uses data provided by patients and collected by the NHS as part of their care and support. ND received funding from Health Data Research UK (MR/S003126/1), which is funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation, and the Wellcome Trust. SKM is funded by an MRC Clinical Academic Research Partnership Award (MR/T02383X/1). The authors would like to thank the Psoriasis Association for ongoing support and funding since the inception of BSTOP (reference: RG2/10: RG2/10). The authors also acknowledge the invaluable support of the National Institute for Health and Care Research through the clinical research networks and its contribution in facilitating recruitment to BSTOP. Members of the BSTOP Study Group who contributed to the collection of valuable clinical information and samples for profiling (excluding individually named authors of this work) are Nadia Aldoori, Mahmud Ali, Alex Anstey, Fiona Antony, Charles Archer, Suzanna August, Periasamy Balasubramaniam, Kay Baxter, Anthony Bewley, Alexandra Bonsall, Victoria Brown, Katya Burova, Aamir Butt, Mel Caswell, Sandeep Cliff, Mihaela Costache, Sharmela Darne, Emily Davies, Claudia DeGiovanni, Trupti Desai, Bernadette DeSilva, Victoria Diba, Eva Domanne, Harvey Dymond, Caoimhe Fahy, Leila Ferguson, Maria-Angeliki Gkini, Alison Godwin, Fiona Hammonds, Sarah Johnson, Teresa Joseph, Manju Kalavala, Mohsen Khorshid, Liberta Labinoti, Nicole Lawson, Alison Layton, Tara Lees, Nick Levell, Helen Lewis, Calum Lyon, Sandy McBride, Sally McCormack, Kevin McKenna, Serap Mellor, Ruth Murphy, Paul Norris, Caroline Owen, Urvi Popli, Gay Perera, Nabil Ponnambath, Helen Ramsay, Aruni Ranasinghe, Saskia Reeken, Rebecca Rose, Rada Rotarescu, Ingrid Salvary, Kathy Sands, Tapati Sinha, Simina Stefanescu, Kavitha Sundararaj, Kathy Taghipour, Michelle Taylor, Michelle Thomson, Joanne Topliffe, Roberto Verdolini, Rachel Wachsmuth, Martin Wade, Shyamal Wahie, Sarah Walsh, Shernaz Walton, Louise Wilcox, and Andrew Wright. Conceptualization: ND; Data Curation: SKM, CHS; Formal Analysis: JRS, KBH; Funding Acquisition: JNB, MAS, CHS, ND; Investigation: JRS, KBH; Methodology: JRS, ND; Project Administration: CHS, ND; Resources: LCT, JTE; Supervision: JNB, MAS, CHS, ND; Writing - Original Draft Preparation: JRS, ND; Writing - Review and Editing: JRS, KBH, SKM, LCT, JTE, JNB, MAS, CHS, ND

PY - 2023/8

Y1 - 2023/8

UR - http://www.scopus.com/inward/record.url?scp=85159281138&partnerID=8YFLogxK

U2 - 10.1016/j.jid.2023.02.010

DO - 10.1016/j.jid.2023.02.010

M3 - Letter

C2 - 36870556

SN - 0022-202X

VL - 143

SP - 1598-1601.e10

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 8

ER -