@article{48960eb4723d4a388233c67bc10c3073,
title = "Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk",
abstract = "Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.",
keywords = "Africa, Asia, Blood Pressure, Cardiovascular Diseases, Coronary Artery Disease, Europe, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Hypertension, Kidney Diseases, Polymorphism, Single Nucleotide, Stroke",
author = "Ehret, {Georg B} and Munroe, {Patricia B} and Rice, {Kenneth M} and Murielle Bochud and Johnson, {Andrew D} and Chasman, {Daniel I} and Smith, {Albert V} and Tobin, {Martin D} and Verwoert, {Germaine C} and Shih-Jen Hwang and Vasyl Pihur and Peter Vollenweider and Paul O'Reilly and Najaf Amin and Bragg-Gresham, {Jennifer L} and Alexander Teumer and Glazer, {Nicole L} and Lenore Launer and Zhao, {Jing Hua} and Yurii Aulchenko and Simon Heath and Siim S{\~o}ber and Afshin Parsa and Jian'an Luan and Pankaj Arora and Abbas Dehghan and Feng Zhang and Gavin Lucas and Hicks, {Andrew A} and Jackson, {Anne U} and Peden, {John F} and Toshiko Tanaka and Wild, {Sarah H} and Igor Rudan and Wilmar Igl and Yuri Milaneschi and Parker, {Alex N} and Cristiano Fava and Chambers, {John C} and Fox, {Ervin R} and Meena Kumari and Go, {Min Jin} and {van der Harst}, Pim and Kao, {Wen Hong Linda} and Andrew Wong and Spector, {Tim D} and Guangju Zhai and Morris, {Richard W} and Wilson, {James F} and {International Consortium for Blood Pressure Genome-Wide Association Studies} and {Hernandez Fuentes}, Maria",
year = "2011",
month = oct,
day = "6",
doi = "10.1038/nature10405",
language = "English",
volume = "478",
pages = "103--109",
journal = "NATURE",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7367",
}